Sunitinib - Small Molecule (ID:10175-106)
| HMS LINCS ID: |
10175-106
|
| Name: | Sunitinib |
| Alternative Names: | Sutent; SU11248 |
| LINCS ID: | LSM-42800 |
| PubChem CID: | 3086686 |
| ChEBI ID: | |
| ChEMBL ID: | 535 |
| Molecular Mass: | 398.21 |
| InChi: | InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28) |
| InChi Key: | WINHZLLDWRZWRT-UHFFFAOYSA-N |
| SMILES: | CCN(CC)CCNC(=O)C1=C(NC(=C1C)C=C2C3=C(C=CC(=C3)F)NC2=O)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2018-03-30 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AAK1, AXL, BLK, BMP2K, CAMK2A, CHEK2, CLK1, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1E, DAPK3, FLT1, FLT3, FLT4, GAK, HIPK1, HIPK2, HIPK3, IRAK1, IRAK4, ITK, JAK1, KDR, KIT, LRRK2, MAP2K5, MAP3K13, MAP3K19, MAP3K2, MAP3K7, MAP4K1, MAP4K2, MAP4K5, MERTK, MINK1, MST1, MYLK2, MYLK3, MYLK4, NUAK1, PAK3, PDGFRA, PDGFRB, PHKG1, PHKG2, PIP4K2B, pknB, PRKAA1, PRKAA2, PTK2B, RET, RIOK1, RIOK2, RPS6KA2, RPS6KB1, SLK, SRPK3, STK10, STK11, STK17A, STK24, STK3, STK33, STK4, TNIK, TPTEP2-CSNK1E, TTK, TYRO3, ULK1, ULK2, ULK3 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, AIM1, ALK, ANKK1, AURKB, AURKC, BMPR2, C8orf44-SGK3, CAMK1, CAMK1D, CAMK1G, CAMK2D, CAMK2G, CAMK4, CAMKK1, CDK14, CDK16, CDK7, CHEK1, CHUK, CSNK1A1L, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DCLK1, DCLK3, DLK1, DYRK1A, DYRK2, EIF2AK2, EIF2AK4, EPHA6, EPHB1, EPHB6, ERN1, FES, FGFR1, FGFR2, FGFR3, FGR, FLG, FRK, FYN, GCK, GRK1, GRK4, GRK7, HCK, HIPK4, HUNK, ICK, IGF1R, IKBKE, INSR, INSRR, IRAK3, JAK2, KCNH2, LATS1, LATS2, LCK, LYN, MAP2K1, MAP2K1, MAP2K2, MAP2K4, MAP3K11, MAP3K12, MAP3K3, MAP4K3, MAP4K4, MARK2, MARK3, MAST1, MELK, MUSK, MYLK, NIM1K, NTRK1, NTRK2, NUAK2, OSR1, OXSR1, PAK5, PHKA2, PKD1, PKD2, PKN1, PLK4, PRKAB1, PRKAB2, PRKD1, PRKD2, PRKD3, PRPF4, PRPF4B, PTK2, RIPK1, ROCK1, ROCK2, RPS6KA1, RPS6KA3, RPS6KA4, RPS6KA5, SBK1, SGK2, SGK3, SIK2, SNRK, SRC, SRPK1, SRPK2, STK16, STK17B, STK25, STK26, Stk3, STK38, STK38L, STK39, TAOK1, TAOK3, TBK1, TLK1, TLK2, TNK1, TSSK2, TYK2, Ulk3, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL2, AKT2, AURKA, BMPR1B, BRSK1, BRSK2, BTK, BUB1B-PAK6, CAMK2B, CAMKK2, CDC7, CDK1, CDK17, CDK18, CDK4, CDK5, CDKL2, CIT, DCLK2, DDR1, DDR2, DSTYK, DYRK1B, DYRK3, DYRK4, EEF2K, EGFR, EPHA3, EPHA5, EPHA7, EPHB4, FER, FGFR4, GRK5, JAK3, LTK, MAP2K3, MAP2K6, MAP3K15, MAP3K4, MAP3K9, MAPK10, MAPK7, MAPK9, MARK1, MARK4, MATK, MET, MKNK1, MKNK2, MYO3A, MYO3B, NEK2, NEK4, NEK7, NTRK3, PAK4, PAK6, PDK1, PDPK1, PF3D7_0217500, PIM3, PIP5K1A, PKN2, PLK2, PRKCA, PRKCG, PRKCI, PRKCQ, PRKCZ, PTK6, RIOK3, RIPK4, RPS6KA6, SBK3, SIK1, SIK1B, SRC, STK35, TIE1, TNK2, TNKS2, TSSK1B, WEE1 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20120 | Metrics other than potency reveal systematic variation in responses to cancer drugs | Analysis |
| 20268 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. | Analysis |
| 20269 | Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. | Analysis |
| 20270 | Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen. | Analysis |
| 20324 | Tyrosine Kinase Inhibitor-induced cardiotoxicity in hiPSC derived cardiomyocytes - pilot dataset | RNA-Seq |
| 20325 | Tyrosine Kinase Inhibitor-induced cardiotoxicity in hiPSC derived cardiomyocytes - pilot dataset (qPCR validation) | qPCR |
| 20349 | Tyrosine Kinase Inhibitor-induced cardiotoxicity in hiPSC derived cardiomyocytes - Proteomics | Proteomics |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10175-106-1 | Haoyuan chemexpress | HY-10255-20110826 |
| 10175-106-3 | LC Laboratories | |
| 10175-106-4 | Haoyuan chemexpress | 08828 |
(Kd <100 nM)