SB 203580 - Small Molecule (ID:10167-101)
| HMS LINCS ID: |
10167-101
|
| Name: | SB 203580 |
| Alternative Names: | RWJ 64809; PB 203580 |
| LINCS ID: | LSM-1168 |
| PubChem CID: | 176155 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 377.10 |
| InChi: | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| InChi Key: | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| SMILES: | CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CSNK1A1, CSNK1D, GAK, GCGR, MAPK10, MAPK11, MAPK12, MAPK13, Mapk14, MAPK14, NLK, RIPK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | BRAF, CDC42BPG, CIT, CSNK1E, MAPK9, PF3D7_0217500, RAF1, RPS6KA1, RPS6KA6, TBXAS1, TNIK, TPTEP2-CSNK1E |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL1, ACVR1B, BMPR1B, CDC42BPA, CDC42BPB, CDC7, CDK1, CHEK2, CHUK, COQ8B, CSNK1A1L, DDR1, DDR2, DYRK1A, DYRK3, DYRK4, EEF2K, EGFR, EPHA6, EPHB2, EPHB6, ERBB4, FPGT-TNNI3K, FRK, GRK5, GSK3B, HIPK2, HIPK4, IKBKB, IRAK1, LCK, MAP2K2, MAP2K5, MAP3K20, MAP4K2, MAP4K4, MAPK8, MATK, MET, MINK1, MST1R, MT-CO1, NEK4, P2RX7, PIP5K1C, PTGS1, PTK6, ROCK1, ROCK2, RPS6KB1, SGK2, SIK3, SLK, SRC, STK32A, STK32B, STK36, TAOK1, TBK1, TGFBR1, TGFBR2, TKT, TNNI3K, TSSK2, TTK, TXK, TYK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10167-101-1 | Haoyuan chemexpress | HY-10256_1-20100610 |
(Kd <100 nM)