AZD 5438 - Small Molecule (ID:10158-101)
| HMS LINCS ID: |
10158-101
|
| Name: | AZD 5438 |
| Alternative Names: | KIN001-239 |
| LINCS ID: | LSM-1159 |
| PubChem CID: | 16747683 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 371.14 |
| InChi: | InChI=1S/C18H21N5O2S/c1-12(2)23-13(3)20-11-17(23)16-9-10-19-18(22-16)21-14-5-7-15(8-6-14)26(4,24)25/h5-12H,1-4H3,(H,19,21,22) |
| InChi Key: | WJRRGYBTGDJBFX-UHFFFAOYSA-N |
| SMILES: | CC1=NC=C(N1C(C)C)C2=NC(=NC=C2)NC3=CC=C(C=C3)S(=O)(=O)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CCNA2, CCNB1, CCND3, CCNE1, CCNT1, CDK1, CDK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CDK16, CDK4, CDK7, CDK9, CSNK1E, CSNK2A2, JAK2, JAK3, MAP2K4, MAP3K19, MAPK10, MAPK15, MAPK8, MAPK9, STK17A, STK17B, TPTEP2-CSNK1E |
3 (equivalent to 1µM ≤ Kd < 10 µM) | KCNH2 |
10 (confirmed non-binding) |
Batch Information for HMSL10158-101-1:
| HMS LINCS Batch ID: | 10158-101-1 |
| Provider: | Haoyuan chemexpress |
| Provider Batch ID: | HY-10012_1-20110610 |
| Salt: | 101 |
| Molecular Formula: | C18H21N5O2S |
| Molecular Weight: | 371.46 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10158-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 04/13/2015 | PASS | HMSL10158-101-1_LCMS.pdf | |
| 11/14/2011 | PASS | None |
(Kd <100 nM)