MK 1775 - Small Molecule (ID:10152-101)
| HMS LINCS ID: |
10152-101
|
| Name: | MK 1775 |
| Alternative Names: | |
| LINCS ID: | LSM-1153 |
| PubChem CID: | 24856436 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 500.26 |
| InChi: | InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31) |
| InChi Key: | BKWJAKQVGHWELA-UHFFFAOYSA-N |
| SMILES: | CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC=C(C=C4)N5CCN(CC5)C)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, CDK5, LCK, LRRK2, NEK2, PRKCQ, SYK, TNK2, WEE1 | |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ACVR1, AIM1, ALK, AURKB, BTK, CAMK1D, CAMK2A, CDK7, CDK8, CHEK1, CLK2, CLK4, CSF1R, CSNK1A1, DAPK3, DYRK1B, FGFR1, FGFR3, FLG, FLT1, FLT3, FYN, GRK5, GSK3A, GSK3B, IGF1R, IKBKE, JAK2, JAK3, LIMK1, LTK, MAP2K1, MAP2K2, MAP4K2, MAP4K4, MAP4K5, MAPK14, MAPK8, MAPK9, MET, MINK1, MST1R, NTRK1, NTRK2, NTRK3, PAK4, PDGFRA, PIM1, PKN2, PRKAA1, PRKD3, PRKX, PTK2, RET, ROCK1, ROS1, RPS6KA3, STK3, TAOK1, TBK1, TYRO3 |
10 (confirmed non-binding) |
Batch Information for HMSL10152-101-2:
| HMS LINCS Batch ID: | 10152-101-2 |
| Provider: | MedChem Express |
| Provider Batch ID: | 03485 |
| Salt: | 101 |
| Molecular Formula: | C27H32N8O2 |
| Molecular Weight: | 500.6 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-06-17 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10152-101-2:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10152-101-2_LCMS.pdf |
(equivalent to 100 nM ≤ Kd < 1µM)