Buparlisib - Small Molecule (ID:10147-101)

HMS LINCS ID: 10147-101
Name: Buparlisib
Alternative Names: BKM120; NVP-BKM120
LINCS ID: LSM-1148
PubChem CID: 16654980
ChEBI ID:
ChEMBL ID:
Molecular Mass: 410.17
InChi: InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)
InChi Key: CWHUFRVAEUJCEF-UHFFFAOYSA-N
SMILES: C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
PIK3CA
2
(equivalent to 100 nM ≤ Kd < 1µM)
PIK3CB, PIK3CD, PIK3CG
3
(equivalent to 1µM ≤ Kd < 10 µM)
MTOR, PIK3C3
10
(confirmed non-binding)
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Batch Information for HMSL10147-101-1:

HMS LINCS Batch ID: 10147-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HM-054_10-20100824
Salt: 101
Molecular Formula: C18H21F3N6O2
Molecular Weight: 410.39
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10147-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10147-101-1_LCMS.pdf
11/14/2011 PASS None