BMS 777607 - Small Molecule (ID:10143-101)
| HMS LINCS ID: |
10143-101
|
| Name: | BMS 777607 |
| Alternative Names: | |
| LINCS ID: | LSM-1144 |
| PubChem CID: | 24794418 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 512.11 |
| InChi: | InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) |
| InChi Key: | VNBRGSXVFBYQNN-UHFFFAOYSA-N |
| SMILES: | CCOC1=C(C(=O)N(C=C1)C2=CC=C(C=C2)F)C(=O)NC3=CC(=C(C=C3)OC4=C(C(=NC=C4)N)Cl)F |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AIM1, AURKB, AXL, FLT3, MERTK, MET, MST1R, TYRO3 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | BLK, EPHA3, KDR, KIT, LCK, MKNK2, MUSK, NTRK1, NTRK2, PDGFRB, SRC, STK10, TEK |
3 (equivalent to 1µM ≤ Kd < 10 µM) | BTK, CHUK, EGFR, FCGR1A, GSK3B, INSR, JAK2, MAPK14, MAPKAPK2, PIM1, PLK1 |
Batch Information for HMSL10143-101-1:
| HMS LINCS Batch ID: | 10143-101-1 |
| Provider: | Haoyuan chemexpress |
| Provider Batch ID: | HY-12076-20110602 |
| Salt: | 101 |
| Molecular Formula: | C25H19ClF2N4O4 |
| Molecular Weight: | 512.89 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2011-07-15 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10143-101-1:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 04/13/2015 | PASS | HMSL10143-101-1_LCMS.pdf | |
| 11/14/2011 | PASS | None |
(Kd <100 nM)