Trametinib - Small Molecule (ID:10142-101)
| HMS LINCS ID: |
10142-101
|
| Name: | Trametinib |
| Alternative Names: | GSK-1120212; GSK1120212; GSK1120212B; JTP-74057 |
| LINCS ID: | LSM-1143 |
| PubChem CID: | 11707110 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 615.08 |
| InChi: | InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34) |
| InChi Key: | LIRYPHYGHXZJBZ-UHFFFAOYSA-N |
| SMILES: | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
MAP2K1, MAP2K2 |
Batch Information for HMSL10142-101-6:
| HMS LINCS Batch ID: | 10142-101-6 |
| Provider: | Selleck Chemicals |
| Provider Batch ID: | |
| Salt: | 101 |
| Molecular Formula: | C26H23FIN5O4 |
| Molecular Weight: | 615.39 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-12-22 |
| Most Recent Update: | 2016-12-22 |
(Kd <100 nM)