Trametinib - Small Molecule (ID:10142-101)

HMS LINCS ID: 10142-101
Name: Trametinib
Alternative Names: GSK-1120212; GSK1120212; GSK1120212B; JTP-74057
LINCS ID: LSM-1143
PubChem CID: 11707110
ChEBI ID:
ChEMBL ID:
Molecular Mass: 615.08
InChi: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
InChi Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N
SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
MAP2K1, MAP2K2

Batch Information for HMSL10142-101-3:

HMS LINCS Batch ID: 10142-101-3
Provider: MedChem Express
Provider Batch ID: 07378
Salt: 101
Molecular Formula: C26H23FIN5O4
Molecular Weight: 615.39
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10142-101-3:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10142-101-3_LCMS.pdf