Masitinib - Small Molecule (ID:10130-999)

HMS LINCS ID: 10130-999
Name: Masitinib
Alternative Names: AB1010
LINCS ID: LSM-1130
PubChem CID: 10074640
ChEBI ID:
ChEMBL ID:
Molecular Mass: 498.22
InChi: InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)
InChi Key: WJEOLQLKVOPQFV-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, CSF1R, DDR1, DDR2, FRK, KIT, LCK, LYN, PDGFRA, PDGFRB, TKT
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL2, BLK, FGR, FYN, HCK, MAP3K20, PIM3, SRC, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
BRAF, EGFR, EPHA3, EPHA8, ERBB2, PIM1, RIOK2
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20170
AB-1010 KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10130-999-2