Masitinib - Small Molecule (ID:10130-999)
| HMS LINCS ID: |
10130-999
|
| Name: | Masitinib |
| Alternative Names: | AB1010 |
| LINCS ID: | LSM-1130 |
| PubChem CID: | 10074640 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 498.22 |
| InChi: | InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32) |
| InChi Key: | WJEOLQLKVOPQFV-UHFFFAOYSA-N |
| SMILES: | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, CSF1R, DDR1, DDR2, FRK, KIT, LCK, LYN, PDGFRA, PDGFRB, TKT | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL2, BLK, FGR, FYN, HCK, MAP3K20, PIM3, SRC, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | BRAF, EGFR, EPHA3, EPHA8, ERBB2, PIM1, RIOK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20170 | AB-1010 KINOMEscan | KINOMEscan |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10130-999-2 |
(Kd <100 nM)