GSK 690693 - Small Molecule (ID:10128-999)
| HMS LINCS ID: |
10128-999
|
| Name: | GSK 690693 |
| Alternative Names: | |
| LINCS ID: | LSM-1128 |
| PubChem CID: | 16048642 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 425.22 |
| InChi: | InChI=1S/C21H27N7O3/c1-4-28-18-15(30-12-13-6-5-9-23-10-13)11-24-14(7-8-21(2,3)29)16(18)25-20(28)17-19(22)27-31-26-17/h11,13,23,29H,4-6,9-10,12H2,1-3H3,(H2,22,27) |
| InChi Key: | KGPGFQWBCSZGEL-UHFFFAOYSA-N |
| SMILES: | CCN1C2=C(C(=NC=C2OCC3CCCNC3)C#CC(C)(C)O)N=C1C4=NON=C4N |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AKT1, AKT2, AKT3, BUB1B-PAK6, MAP3K19, NUAK2, PAK4, PAK5, PAK6, PKN1, pknB, Prkaa2, PRKACA, PRKACB, PRKCB, PRKCD, PRKCE, PRKCH, PRKCQ, PRKG2, PRKX, RPS6KA4 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CAMK4, CIT, CLK2, DAPK3, DCLK3, GRK1, GRK7, GSK3B, HIPK1, HIPK2, HIPK3, LATS2, MAP3K2, MAP3K3, MARK2, MELK, NUAK1, PAK1, PAK2, PIM1, PIM2, PIM3, PRKCI, PRKD3, PRKG1, ROCK1, ROCK2, RPS6KA5, TAOK1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | C8orf44-SGK3, CAMK1D, CHEK2, DAPK1, DCLK1, EIF2AK2, GSK3A, KIT, NLK, PDGFRB, PIP5K1C, PKD1, PKN2, PRKD1, RET, RPS6KA1, SGK3, SIK2, STK26, STK36, TAOK2, TAOK3, ULK1, ULK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20169 | GSK-690693 KINOMEscan | KINOMEscan |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10128-999-2 |
(Kd <100 nM)