Dovitinib - Small Molecule (ID:10127-999)

HMS LINCS ID: 10127-999
Name: Dovitinib
Alternative Names: TKI_258; TKI258
LINCS ID: LSM-1127
PubChem CID: 49830557
ChEBI ID:
ChEMBL ID:
Molecular Mass: 392.18
InChi: InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3
InChi Key: KCOYQXZDFIIGCY-UHFFFAOYSA-N
SMILES: CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, ANKK1, BMP2K, CSF1R, FLT1, FLT3, GRK4, KDR, KIT, MAP2K5, MAP3K19, MAP3K2, MAP4K1, MAST1, MINK1, MYLK2, MYLK3, MYLK4, PDGFRA, PDGFRB, RET, TNIK, ULK1, ULK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
AAK1, AURKB, BLK, C8orf44-SGK3, CDK16, CDKL2, CSNK2A2, EIF2AK4, EPHB6, FGFR1, FGFR2, FGFR3, FGR, FLT4, FYN, GAK, GSK3B, HIPK2, HUNK, IKBKE, IRAK1, IRAK4, ITK, JAK1, JAK2, JAK3, LATS2, LCK, LYN, MAP2K1, MAP2K2, MAP3K13, MAP3K7, MAP4K3, MAP4K4, MAP4K5, MUSK, NIM1K, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PAK3, PF3D7_0217500, PHKG1, PIP4K2B, PKN1, pknB, PLK2, PRKAA1, PRKAA2, PRPF4B, RIOK1, RIOK2, RIOK3, RIPK1, ROCK1, RPS6KA1, RPS6KA2, RPS6KA4, RPS6KA5, RPS6KB1, SGK3, SLK, SRPK1, SRPK2, SRPK3, STK10, STK17A, STK24, STK26, STK3, STK38, STK39, STK4, TBK1, ULK3, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ALK, AURKC, AXL, BMPR2, CAMKK1, CDK17, CDK18, CDK4, CDK7, CHEK1, CHUK, CIT, CLK1, CLK2, CLK4, CSNK2A1, DCLK3, DDR1, DDR2, DYRK2, EGFR, EIF2AK2, FGFR4, FRK, GRK1, GRK7, HCK, HIPK1, HIPK3, LATS1, LRRK2, MAP3K11, MAP3K12, MAP3K4, MAP3K9, MAP4K2, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MYLK, NEK2, NEK4, NEK5, NEK6, NEK7, NEK9, PHKG2, PIP5K1A, PIP5K1C, PKN2, PRKCQ, ROCK2, RPS6KA3, RPS6KA6, SBK1, SIK2, SRC, STK11, STK16, STK17B, STK25, TIE1, TLK2, TYK2, TYRO3, WEE1

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20168
TKI-258 KINOMEscan
 KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10127-999-2