Dovitinib - Small Molecule (ID:10127-101)
| HMS LINCS ID: |
10127-101
|
| Name: | Dovitinib |
| Alternative Names: | TKI_258; TKI258 |
| LINCS ID: | LSM-1127 |
| PubChem CID: | 49830557 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 392.18 |
| InChi: | InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11,24-25H,7-10,23H2,1H3 |
| InChi Key: | KCOYQXZDFIIGCY-UHFFFAOYSA-N |
| SMILES: | CN1CCN(CC1)C2=CC3=C(C=C2)NC(=C4C(=C5C(=NC4=O)C=CC=C5F)N)N3 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, ANKK1, BMP2K, CSF1R, FLT1, FLT3, GRK4, KDR, KIT, MAP2K5, MAP3K19, MAP3K2, MAP4K1, MAST1, MINK1, MYLK2, MYLK3, MYLK4, PDGFRA, PDGFRB, RET, TNIK, ULK1, ULK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AAK1, AURKB, BLK, C8orf44-SGK3, CDK16, CDKL2, CSNK2A2, EIF2AK4, EPHB6, FGFR1, FGFR2, FGFR3, FGR, FLT4, FYN, GAK, GSK3B, HIPK2, HUNK, IKBKE, IRAK1, IRAK4, ITK, JAK1, JAK2, JAK3, LATS2, LCK, LYN, MAP2K1, MAP2K2, MAP3K13, MAP3K7, MAP4K3, MAP4K4, MAP4K5, MUSK, NIM1K, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PAK3, PF3D7_0217500, PHKG1, PIP4K2B, PKN1, pknB, PLK2, PRKAA1, PRKAA2, PRPF4B, RIOK1, RIOK2, RIOK3, RIPK1, ROCK1, RPS6KA1, RPS6KA2, RPS6KA4, RPS6KA5, RPS6KB1, SGK3, SLK, SRPK1, SRPK2, SRPK3, STK10, STK17A, STK24, STK26, STK3, STK38, STK39, STK4, TBK1, ULK3, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ALK, AURKC, AXL, BMPR2, CAMKK1, CDK17, CDK18, CDK4, CDK7, CHEK1, CHUK, CIT, CLK1, CLK2, CLK4, CSNK2A1, DCLK3, DDR1, DDR2, DYRK2, EGFR, EIF2AK2, FGFR4, FRK, GRK1, GRK7, HCK, HIPK1, HIPK3, LATS1, LRRK2, MAP3K11, MAP3K12, MAP3K4, MAP3K9, MAP4K2, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MYLK, NEK2, NEK4, NEK5, NEK6, NEK7, NEK9, PHKG2, PIP5K1A, PIP5K1C, PKN2, PRKCQ, ROCK2, RPS6KA3, RPS6KA6, SBK1, SIK2, SRC, STK11, STK16, STK17B, STK25, TIE1, TLK2, TYK2, TYRO3, WEE1 |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20237 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 1 of 15: Cell count and relative growth within biological replicate 1. | Microscopy/Imaging |
| 20238 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 2 of 15: Cell count and relative growth within biological replicate 2. | Microscopy/Imaging |
| 20239 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 3 of 15: Cell count and relative growth within biological replicate 3. | Microscopy/Imaging |
| 20240 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 4 of 15: Mean cell count and mean growth rate across biological replicate 1. | Microscopy/Imaging |
| 20241 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. | Microscopy/Imaging |
| 20242 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 6 of 15: Mean cell count and mean growth rate across biological replicate 3. | Microscopy/Imaging |
| 20243 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 7 of 15: Mean cell count and mean growth rate across all replicates. | Microscopy/Imaging |
| 20245 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 8 of 15: Cell count and normalized growth rate inhibition values within biological replicate 1. | Microscopy/Imaging |
| 20246 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 9 of 15: Cell count and normalized growth rate inhibition values within biological replicate 2. | Microscopy/Imaging |
| 20247 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 10 of 15: Cell count and normalized growth rate inhibition values within biological replicate 3. | Microscopy/Imaging |
| 20248 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. | Microscopy/Imaging |
| 20249 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 12 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 2. | Microscopy/Imaging |
| 20250 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 13 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 3. | Microscopy/Imaging |
| 20251 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 14 of 15: Mean cell count and mean normalized growth rate inhibition values across all replicates. | Microscopy/Imaging |
| 20252 | LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 15 of 15: Calculated dose-response metrics. | Analysis |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10127-101-1 | Haoyuan chemexpress | HY-50905-20110826 |
(Kd <100 nM)