HMS LINCS Project

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PI103 - Small Molecule (ID:10126-999)

HMS LINCS ID:	10126-999
Name:	PI103
Alternative Names:
LINCS ID:	LSM-1126
PubChem CID:	9884685
ChEBI ID:
ChEMBL ID:	538346
Molecular Mass:	348.12
InChi:	InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
InChi Key:	TUVCWJQQGGETHL-UHFFFAOYSA-N
SMILES:	C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update:	2016-07-12

Target Affinity:

(see Study 20000)

Target Affinity Spectrum Value	HUGO Gene Name
1 (Kd <100 nM)	FKBP1A, MTOR, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PRKDC
2 (equivalent to 100 nM ≤ Kd < 1µM)	DAPK3, HIPK2, HIPK3, MAP3K19, PIP4K2C, RIOK2
3 (equivalent to 1µM ≤ Kd < 10 µM)	BRAF, CDC42BPA, CDK1, CDK7, CHUK, CLK1, CLK2, CLK3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DYRK1B, DYRK2, FLT3, HIPK1, HIPK4, IRAK1, JAK1, LIMK2, MAPK13, MINK1, MYLK, PI4KB, PIK3C2A, PRKCG, PRKCZ, RAF1, SGK2, TYK2
10 (confirmed non-binding)	(Click to show)AAK1, ABL1, ABL2, ACVR1, ACVR1B, ACVR2A, ACVR2B, ACVRL1, AIM1, AKT1, AKT2, AKT3, ALK, ANKK1, AURKA, AURKB, AURKC, AXL, BLK, BMP2K, BMPR1A, BMPR1B, BMPR2, BMX, BRSK1, BRSK2, BTK, CAMK1, CAMK1D, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CASK, CDC42BPB, CDC42BPG, CDK11A, CDK11B, CDK13, CDK14, CDK15, CDK16, CDK17, CDK18, CDK19, CDK2, CDK3, CDK4, CDK5, CDK8, CDK9, CDKL1, CDKL2, CDKL3, CDKL5, CDKN3, CHEK1, CHEK2, CIT, CLK4, CSF1R, CSK, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DCLK1, DCLK2, DCLK3, DDR1, DDR2, DMPK, DSTYK, DYRK1A, EGFR, EIF2AK1, EIF2AK2, EIF2AK4, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB2, ERBB3, ERBB4, ERN1, FER, FES, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLG, FLT1, FLT4, FRK, FYN, GAK, GRK1, GRK4, GRK7, GSK3A, GSK3B, HCK, HUNK, ICK, IGF1R, IKBKB, IKBKE, INSR, INSRR, IRAK3, IRAK4, ITK, JAK2, JAK3, KDR, KIT, LATS1, LATS2, LCK, LIMK1, LRRK2, LTK, LYN, MAK, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K15, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK14, MAPK15, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MARK1, MARK2, MARK3, MARK4, MAST1, MATK, MELK, MERTK, MET, MKNK1, MKNK2, MST1, MST1R, MUSK, MYLK2, MYLK3, MYLK4, MYO3A, MYO3B, MYT1, NEK1, NEK11, NEK2, NEK3, NEK4, NEK5, NEK6, NEK7, NEK8, NEK9, NIM1K, NLK, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, OSR1, OXSR1, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, PBK, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKG1, PHKG2, PIM1, PIM2, PIM3, PIP4K2B, PIP5K1A, PIP5K1C, PKD1, PKD2, PKMYT1, PKN1, PKN2, PLK1, PLK2, PLK3, PLK4, PRKAA1, PRKAA2, PRKACA, PRKACB, PRKCD, PRKCE, PRKCH, PRKCI, PRKCQ, PRKD1, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PRPF4B, PTK2, PTK2B, PTK6, RET, RIOK1, RIOK3, RIPK1, RIPK2, RIPK4, ROCK1, ROCK2, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RPS6KB1, SBK1, SBK3, SGK3, SIK1, SIK2, SIK3, SLK, SNRK, SRC, SRMS, SRPK1, SRPK2, SRPK3, STK10, STK11, STK16, STK17A, STK17B, STK24, STK25, STK26, STK3, STK32A, STK32B, STK32C, STK33, STK35, STK36, STK38, STK38L, STK39, STK4, SYK, TAOK1, TAOK2, TAOK3, TBK1, TEC, TEK, TESK1, TGFBR1, TGFBR2, TIE1, TKT, TLK1, TLK2, TNIK, TNK1, TNK2, TNNI3K, TRPM6, TSSK1B, TTK, Tuba1a, TXK, TYRO3, ULK1, ULK2, ULK3, VRK2, WEE1, WEE2, YES1, ZAP70

Datasets:

HMS Dataset ID	Dataset Title	HMS Dataset Type
20000	Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.	Analysis
20167	PI-103 KINOMEscan	KINOMEscan

Batch Information:

HMS LINCS Batch ID	Provider	Provider Batch ID
10126-999-3

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