PI103 - Small Molecule (ID:10126-102)
| HMS LINCS ID: |
10126-102
|
| Name: | PI103 |
| Alternative Names: | |
| LINCS ID: | LSM-1126 |
| PubChem CID: | 9884685 |
| ChEBI ID: | |
| ChEMBL ID: | 538346 |
| Molecular Mass: | 348.12 |
| InChi: | InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2 |
| InChi Key: | TUVCWJQQGGETHL-UHFFFAOYSA-N |
| SMILES: | C1COCCN1C2=NC(=NC3=C2OC4=C3C=CC=N4)C5=CC(=CC=C5)O |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
FKBP1A, MTOR, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PRKDC | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | DAPK3, HIPK2, HIPK3, MAP3K19, PIP4K2C, RIOK2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | BRAF, CDC42BPA, CDK1, CDK7, CHUK, CLK1, CLK2, CLK3, CSNK2A1, CSNK2A2, DAPK1, DAPK2, DYRK1B, DYRK2, FLT3, HIPK1, HIPK4, IRAK1, JAK1, LIMK2, MAPK13, MINK1, MYLK, PI4KB, PIK3C2A, PRKCG, PRKCZ, RAF1, SGK2, TYK2 |
10 (confirmed non-binding) |
Datasets:
| HMS Dataset ID | Dataset Title | HMS Dataset Type |
|---|---|---|
| 20000 | Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library. | Analysis |
| 20233 | Synovial Fibroblast 1: Secretion response of primary human synovial fibroblast samples from one healthy and one rheumatoid arthritis donor to a panel of 10 stimuli and 10 small molecule inhibitors | Bead-based immunoassay |
Batch Information:
| HMS LINCS Batch ID | Provider | Provider Batch ID |
|---|---|---|
| 10126-102-2 | Tocris | reference date: Oct 2010 |
| 10126-102-4 | MedChem Express | 05624 |
| 10126-102-5 | Tocris |
(Kd <100 nM)