PHA-665752 - Small Molecule (ID:10125-101)

HMS LINCS ID: 10125-101
Name: PHA-665752
Alternative Names:
LINCS ID: LSM-42793
PubChem CID: 66596670
ChEBI ID:
ChEMBL ID: 450786
Molecular Mass: 640.17
InChi: InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/t21-/m1/s1
InChi Key: OYONTEXKYJZFHA-OAQYLSRUSA-N
SMILES: CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)C=C4C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
BMP2K, CAMKK1, CAMKK2, DDR1, GRK7, HIPK1, HIPK3, MAP3K19, MAP4K5, MET, SRPK1, TAOK3
2
(equivalent to 100 nM ≤ Kd < 1µM)
AAK1, AURKC, AXL, CDK15, CDK17, CDK7, CLK1, CLK2, CSF1R, CSNK1E, DCLK2, FLT3, GRK4, HIPK2, ICK, IKBKE, IRAK3, JAK2, JAK3, LCK, MAK, MAP2K2, MAP3K12, MAP4K1, MAP4K3, MAP4K4, MINK1, MST1R, MYLK2, NEK2, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PIP5K1A, PLK4, PRKAA1, PRKAA2, PTK2B, RET, RIOK1, RIOK3, SLK, SRPK2, STK10, STK33, TAOK1, TBK1, TNIK, TPTEP2-CSNK1E
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, AIM1, ALK, AURKB, BLK, BMPR2, CAMK1, CAMK1D, CAMK2A, CAMK2D, CAMK2G, CASK, CDK14, CDK16, CDK18, CDK4, CDK9, CDKL2, CLK3, CSNK1D, CSNK2A2, DCLK1, DCLK3, DDR2, EIF2AK4, EPHA8, EPHB6, FGFR1, FGFR2, FGFR3, FGR, FLG, FLT4, GAK, GRK1, HIPK4, HUNK, INSR, INSRR, IRAK1, IRAK4, JAK1, KDR, KIT, MAP2K1, MAP2K5, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K7, MAP4K2, MAPK7, MARK2, MERTK, MYLK, NIM1K, PAK1, PAK3, PAK5, PDGFRA, PDGFRB, PHKG1, PHKG2, PIP4K2B, PLK2, PRPF4B, PTK2, RIPK1, ROCK2, ROS1, RPS6KA3, RPS6KA5, RPS6KA6, RPS6KB1, SIK2, SRC, SRPK3, STK11, STK16, STK17A, STK17B, STK26, STK3, TAOK2, TEK, TIE1, TKT, TSSK1B, TYK2, TYRO3, ULK1, ULK2, YES1
10
(confirmed non-binding)
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Batch Information for HMSL10125-101-1:

HMS LINCS Batch ID: 10125-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-11107-20110919
Salt: 101
Molecular Formula: C32H34Cl2N4O4S
Molecular Weight: 641.61
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10125-101-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10125-101-1_NMR.pdf,
HMSL10125-101-1_LCMS.pdf
11/14/2011 PASS None