LDN-193189 - Small Molecule (ID:10115-102)
| HMS LINCS ID: |
10115-102
|
| Name: | LDN-193189 |
| Alternative Names: | DM 3189 |
| LINCS ID: | LSM-1115 |
| PubChem CID: | 25195294 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 406.19 |
| InChi: | InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 |
| InChi Key: | CDOVNWNANFFLFJ-UHFFFAOYSA-N |
| SMILES: | C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ACVR1, ACVRL1, BMP4, BMPR1A, BMPR1B | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, ABL2, BRSK2, CAMKK2, CLK2, CSNK1D, CSNK1D, DYRK1A, FGFR1, FLT1, GCK, KDR, LCK, MAP3K11, MAP3K7, MAPK15, MARK1, MARK3, MARK4, MELK, MINK1, NUAK1, PHKA2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PTK6, RIPK2, RPS6KA1, SRC, SRC, STK33, TBK1, TEK, TGFBR1, TGFBR2, YES1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ACVR1B, BMPR2 |
10 (confirmed non-binding) |
Batch Information for HMSL10115-102-2:
| HMS LINCS Batch ID: | 10115-102-2 |
| Provider: | MedChem Express |
| Provider Batch ID: | 06241 |
| Salt: | 102 |
| Molecular Formula: | C25H26Cl4N6 |
| Molecular Weight: | 552.33 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-06-17 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10115-102-2:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10115-102-2_LCMS.pdf |
(Kd <100 nM)