LDN-193189 - Small Molecule (ID:10115-102)

HMS LINCS ID: 10115-102
Name: LDN-193189
Alternative Names: DM 3189
LINCS ID: LSM-1115
PubChem CID: 25195294
ChEBI ID:
ChEMBL ID:
Molecular Mass: 406.19
InChi: InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
InChi Key: CDOVNWNANFFLFJ-UHFFFAOYSA-N
SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ACVR1, ACVRL1, BMP4, BMPR1A, BMPR1B
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, ABL2, BRSK2, CAMKK2, CLK2, CSNK1D, CSNK1D, DYRK1A, FGFR1, FLT1, GCK, KDR, LCK, MAP3K11, MAP3K7, MAPK15, MARK1, MARK3, MARK4, MELK, MINK1, NUAK1, PHKA2, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PTK6, RIPK2, RPS6KA1, SRC, SRC, STK33, TBK1, TEK, TGFBR1, TGFBR2, YES1
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR1B, BMPR2
10
(confirmed non-binding)
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Batch Information for HMSL10115-102-1:

HMS LINCS Batch ID: 10115-102-1
Provider: Axon
Provider Batch ID:
Salt: 102
Molecular Formula: C25H24Cl2N6
Molecular Weight: 479.4
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-12-02

HMS QC Testing Events for HMSL10115-102-1:

Date HMS QC Outcome Comment Files
04/13/2015 PASS HMSL10115-102-1_LCMS.pdf
01/10/2012 PASS None