Pazopanib - Small Molecule (ID:10114-999)
| HMS LINCS ID: |
10114-999
|
| Name: | Pazopanib |
| Alternative Names: | GW786034; Votrient |
| LINCS ID: | LSM-1114 |
| PubChem CID: | 10113978 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 437.16 |
| InChi: | InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25) |
| InChi Key: | CUIHSIWYWATEQL-UHFFFAOYSA-N |
| SMILES: | CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CSF1R, DDR1, DDR2, EPHB6, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB, STK10, TAOK3, TKT | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, AURKC, BRAF, FGFR1, FGFR2, FGFR3, FLG, FRK, GAK, IRAK3, LIMK1, LIMK2, LYN, MAP2K4, MAP2K5, MAP3K11, MAP3K19, MAP3K2, MAP3K9, MAP4K1, NEK2, PF3D7_0217500, PI4KB, PIP4K2C, PLK4, RAF1, RET, RIOK2, RIPK1, RIPK2, ROS1, SLK, STK16, STK36, TAOK1, TIE1, TNIK, TTK |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AAK1, ABL2, ACVR2B, ALK, AURKA, BLK, BMP2K, BMPR1B, CAMK1, CAMK1G, CDK11A, CDK11B, CDK16, CSNK1A1, DYRK1A, EIF2AK2, FER, FES, FGFR4, FGR, FLT3, FYN, GRK5, HCK, IRAK1, JAK2, JAK3, LCK, LTK, MAP2K6, MAP3K1, MAP3K10, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK10, MAPK8, MARK3, MERTK, MET, MST1R, MYLK2, NEK5, NLK, PIP5K1C, PTK6, ROCK1, SIK1, SIK1B, SIK2, SRC, SRMS, SYK, TAOK2, TBK1, TEK, TGFBR2, TNK1, TXK, TYK2, YES1 |
10 (confirmed non-binding) |
Batch Information for HMSL10114-999-3:
| HMS LINCS Batch ID: | 10114-999-3 |
| Provider: | |
| Provider Batch ID: | |
| Salt: | 999 |
| Molecular Formula: | |
| Molecular Weight: | |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-05-27 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)