Pazopanib - Small Molecule (ID:10114-101)

HMS LINCS ID: 10114-101
Name: Pazopanib
Alternative Names: GW786034; Votrient
LINCS ID: LSM-1114
PubChem CID: 10113978
ChEBI ID:
ChEMBL ID:
Molecular Mass: 437.16
InChi: InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChi Key: CUIHSIWYWATEQL-UHFFFAOYSA-N
SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CSF1R, DDR1, DDR2, EPHB6, FLT1, FLT4, KDR, KIT, PDGFRA, PDGFRB, STK10, TAOK3, TKT
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, AURKC, BRAF, FGFR1, FGFR2, FGFR3, FLG, FRK, GAK, IRAK3, LIMK1, LIMK2, LYN, MAP2K4, MAP2K5, MAP3K11, MAP3K19, MAP3K2, MAP3K9, MAP4K1, NEK2, PF3D7_0217500, PI4KB, PIP4K2C, PLK4, RAF1, RET, RIOK2, RIPK1, RIPK2, ROS1, SLK, STK16, STK36, TAOK1, TIE1, TNIK, TTK
3
(equivalent to 1µM ≤ Kd < 10 µM)
AAK1, ABL2, ACVR2B, ALK, AURKA, BLK, BMP2K, BMPR1B, CAMK1, CAMK1G, CDK11A, CDK11B, CDK16, CSNK1A1, DYRK1A, EIF2AK2, FER, FES, FGFR4, FGR, FLT3, FYN, GRK5, HCK, IRAK1, JAK2, JAK3, LCK, LTK, MAP2K6, MAP3K1, MAP3K10, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK10, MAPK8, MARK3, MERTK, MET, MST1R, MYLK2, NEK5, NLK, PIP5K1C, PTK6, ROCK1, SIK1, SIK1B, SIK2, SRC, SRMS, SYK, TAOK2, TBK1, TEK, TGFBR2, TNK1, TXK, TYK2, YES1
10
(confirmed non-binding)
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Batch Information for HMSL10114-101-4:

HMS LINCS Batch ID: 10114-101-4
Provider: MedChem Express
Provider Batch ID: 12912
Salt: 101
Molecular Formula: C21H23N7O2S
Molecular Weight: 437.52
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-06-17
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10114-101-4:

Date HMS QC Outcome Comment Files
08/31/2015 PASS HMSL10114-101-4_LCMS.pdf