Staurosporine - Small Molecule (ID:10103-999)

HMS LINCS ID: 10103-999
Name: Staurosporine
Alternative Names: AM-2282; STS
LINCS ID: LSM-1103
PubChem CID: 44259
ChEBI ID:
ChEMBL ID: 388978
Molecular Mass: 466.20
InChi: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChi Key: HKSZLNNOFSGOKW-FYTWVXJKSA-N
SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AURKC, AXL, BLK, BMP2K, BRSK1, BRSK2, CAMK1, CAMK1D, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CASK, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCNE1, CCNE2, CCNK, CCNT1, CDC42BPA, CDC42BPB, CDC42BPG, CDK1, CDK13, CDK16, CDK17, CDK2, CDK3, CDK4, CDK5, CDK5R1, CDK6, CDK7, CDK9, CDKN3, CHEK1, CHEK2, CHUK, CLK1, CLK2, CLK4, CSF1R, CYP11B2, DAPK1, DAPK2, DAPK3, DCLK2, DCLK3, DDR1, DDR2, DMPK, DSTYK, DYRK1A, DYRK1B, EIF2AK4, EPHA3, EPHA5, ERN1, FER, FES, FGFR1, FGFR3, FGR, FLG, FLT3, FLT4, FRK, FYN, GAK, GRK1, GRK4, GRK7, GSK3A, GSK3B, HCK, HIPK3, ICK, IKBKE, INSRR, IRAK1, IRAK3, IRAK4, ITK, JAK2, JAK3, KARS, KDR, KIT, LATS1, LATS2, LCK, LRRK2, LTK, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K10, MAP3K11, MAP3K15, MAP3K19, MAP3K2, MAP3K7, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK12, MAPK15, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MINK1, MKNK2, MST1, MUSK, MYLK, MYLK2, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIM1, PIM2, PIM3, PIP4K2B, PIP5K1A, PKD1, PKD2, PKN1, PKN2, PLK4, PRKAA1, PRKAA2, Prkaca, PRKACA, PRKACA, PRKACB, PRKACG, Prkca, PRKCA, Prkcb, PRKCB, Prkcd, PRKCD, Prkce, PRKCE, Prkcg, PRKCG, Prkch, PRKCH, PRKCI, Prkcq, PRKCQ, Prkcz, PRKCZ, PRKD1, PRKD2, PRKD3, PRKG1, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RET, RIOK3, ROCK1, ROCK2, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA5, RPS6KB1, SBK1, SBK3, SGK3, SIK1, SIK2, SIK3, SLK, SNRK, SRC, SRPK1, SRPK2, SRPK3, STK10, STK11, STK17A, STK17B, Stk3, STK3, STK32A, STK32B, STK33, STK38, STK38L, STK4, SYK, TAB1, TAOK1, TAOK2, TAOK3, TBK1, TIE1, TKT, TLK1, TLK2, TNIK, TNK1, TNK2, TSSK1B, TTK, TYK2, ULK1, ULK2, Ulk3, ULK3, YES1, ZAP70
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, ABL2, ACVR1, ACVR1B, AKT1, ANKK1, Blk, BMPR1B, BMX, BTK, CCNH, CDK14, CDK15, CDK18, CDK19, CDK8, CDKL1, CDKL2, CDKL5, CIT, CLK3, CSK, CSNK1A1L, CSNK1E, DCLK1, DYRK2, DYRK3, EGFR, EIF2AK2, EIF2AK3, EPHA1, EPHA2, EPHA4, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB4, FGFR2, FGFR4, FLT1, GCK, HIPK1, HIPK2, HIPK4, HUNK, IGF1R, IKBKB, INSR, LIMK1, MAP2K1, MAP3K1, MAP3K13, MAP3K5, MAP3K6, MAPK1, MAPK10, MAPK13, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MAST1, MATK, MET, MKNK1, MST1R, MYLK3, MYLK4, MYO3A, MYO3B, NEK1, NEK2, NEK5, NIM1K, NLK, OSR1, OXSR1, PI4KB, PIK3C2G, PLK1, PLK2, PLK3, PRKAB1, PRKAB2, PRKCA, PRPF4B, PTK6, RIOK1, RIOK2, RIPK2, RIPK4, SGK1, SRC, SRMS, STK16, STK24, STK25, STK26, STK32C, STK35, STK39, TEK, TESK1, Tuba1a, TXK, TYRO3
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR2A, ACVR2B, BMPR1A, BMPR2, CDKL3, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, CSNK2A2, CSNK2B, ERBB2, LIMK2, MAK, MAP3K12, MAP3K3, MAP3K4, MAPK3, MAPK6, MAPK7, MAPT, NEK11, NEK7, NEK8, NEK9, PIK3CG, PIP5K1C, RAF1, RPS6KA4, RPS6KA6, STK36, TEC, TERT, TGFBR1, TNNI3K, WEE1
10
(confirmed non-binding)
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Batch Information for HMSL10103-999-2:

HMS LINCS Batch ID: 10103-999-2
Provider:
Provider Batch ID:
Salt: 999
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2015-12-10
Most Recent Update: 2016-12-02