Staurosporine - Small Molecule (ID:10103-999)

HMS LINCS ID: 10103-999
Name: Staurosporine
Alternative Names: AM-2282; STS
LINCS ID: LSM-1103
PubChem CID: 44259
ChEBI ID:
ChEMBL ID: 388978
Molecular Mass: 466.20
InChi: InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
InChi Key: HKSZLNNOFSGOKW-FYTWVXJKSA-N
SMILES: C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AAK1, AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AURKC, AXL, BLK, BMP2K, BRSK1, BRSK2, CAMK1, CAMK1D, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CASK, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCNE1, CCNE2, CCNK, CCNT1, CDC42BPA, CDC42BPB, CDC42BPG, CDK1, CDK13, CDK16, CDK17, CDK2, CDK3, CDK4, CDK5, CDK5R1, CDK6, CDK7, CDK9, CDKN3, CHEK1, CHEK2, CHUK, CLK1, CLK2, CLK4, CSF1R, CYP11B2, DAPK1, DAPK2, DAPK3, DCLK2, DCLK3, DDR1, DDR2, DMPK, DSTYK, DYRK1A, DYRK1B, EIF2AK4, EPHA3, EPHA5, ERN1, FER, FES, FGFR1, FGFR3, FGR, FLG, FLT3, FLT4, FRK, FYN, GAK, GRK1, GRK4, GRK7, GSK3A, GSK3B, HCK, HIPK3, ICK, IKBKE, INSRR, IRAK1, IRAK3, IRAK4, ITK, JAK2, JAK3, KARS, KDR, KIT, LATS1, LATS2, LCK, LRRK2, LTK, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K10, MAP3K11, MAP3K15, MAP3K19, MAP3K2, MAP3K7, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK12, MAPK15, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MINK1, MKNK2, MST1, MUSK, MYLK, MYLK2, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIM1, PIM2, PIM3, PIP4K2B, PIP5K1A, PKD1, PKD2, PKN1, PKN2, PLK4, PRKAA1, PRKAA2, Prkaca, PRKACA, PRKACA, PRKACB, PRKACG, Prkca, PRKCA, Prkcb, PRKCB, Prkcd, PRKCD, Prkce, PRKCE, Prkcg, PRKCG, Prkch, PRKCH, PRKCI, Prkcq, PRKCQ, Prkcz, PRKCZ, PRKD1, PRKD2, PRKD3, PRKG1, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RET, RIOK3, ROCK1, ROCK2, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA5, RPS6KB1, SBK1, SBK3, SGK3, SIK1, SIK2, SIK3, SLK, SNRK, SRC, SRPK1, SRPK2, SRPK3, STK10, STK11, STK17A, STK17B, Stk3, STK3, STK32A, STK32B, STK33, STK38, STK38L, STK4, SYK, TAB1, TAOK1, TAOK2, TAOK3, TBK1, TIE1, TKT, TLK1, TLK2, TNIK, TNK1, TNK2, TSSK1B, TTK, TYK2, ULK1, ULK2, Ulk3, ULK3, YES1, ZAP70
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, ABL2, ACVR1, ACVR1B, AKT1, ANKK1, Blk, BMPR1B, BMX, BTK, CCNH, CDK14, CDK15, CDK18, CDK19, CDK8, CDKL1, CDKL2, CDKL5, CIT, CLK3, CSK, CSNK1A1L, CSNK1E, DCLK1, DYRK2, DYRK3, EGFR, EIF2AK2, EIF2AK3, EPHA1, EPHA2, EPHA4, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB4, FGFR2, FGFR4, FLT1, GCK, HIPK1, HIPK2, HIPK4, HUNK, IGF1R, IKBKB, INSR, LIMK1, MAP2K1, MAP3K1, MAP3K13, MAP3K5, MAP3K6, MAPK1, MAPK10, MAPK13, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MAST1, MATK, MET, MKNK1, MST1R, MYLK3, MYLK4, MYO3A, MYO3B, NEK1, NEK2, NEK5, NIM1K, NLK, OSR1, OXSR1, PI4KB, PIK3C2G, PLK1, PLK2, PLK3, PRKAB1, PRKAB2, PRKCA, PRPF4B, PTK6, RIOK1, RIOK2, RIPK2, RIPK4, SGK1, SRC, SRMS, STK16, STK24, STK25, STK26, STK32C, STK35, STK39, TEK, TESK1, Tuba1a, TXK, TYRO3
3
(equivalent to 1µM ≤ Kd < 10 µM)
ACVR2A, ACVR2B, BMPR1A, BMPR2, CDKL3, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, CSNK2A2, CSNK2B, ERBB2, LIMK2, MAK, MAP3K12, MAP3K3, MAP3K4, MAPK3, MAPK6, MAPK7, MAPT, NEK11, NEK7, NEK8, NEK9, PIK3CG, PIP5K1C, RAF1, RPS6KA4, RPS6KA6, STK36, TEC, TERT, TGFBR1, TNNI3K, WEE1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10103-999-2