Staurosporine - Small Molecule (ID:10103-101)
HMS LINCS ID: | 10103-101 |
Name: | Staurosporine |
Alternative Names: | AM-2282; STS |
LINCS ID: | LSM-1103 |
PubChem CID: | 44259 |
ChEBI ID: | |
ChEMBL ID: | 388978 |
Molecular Mass: | 466.20 |
InChi: | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 |
InChi Key: | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
SMILES: | C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
AAK1, AIM1, AKT1, AKT2, AKT3, ALK, AURKA, AURKB, AURKC, AXL, BLK, BMP2K, BRSK1, BRSK2, CAMK1, CAMK1D, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CASK, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCNE1, CCNE2, CCNK, CCNT1, CDC42BPA, CDC42BPB, CDC42BPG, CDK1, CDK13, CDK16, CDK17, CDK2, CDK3, CDK4, CDK5, CDK5R1, CDK6, CDK7, CDK9, CDKN3, CHEK1, CHEK2, CHUK, CLK1, CLK2, CLK4, CSF1R, CYP11B2, DAPK1, DAPK2, DAPK3, DCLK2, DCLK3, DDR1, DDR2, DMPK, DSTYK, DYRK1A, DYRK1B, EIF2AK4, EPHA3, EPHA5, ERN1, FER, FES, FGFR1, FGFR3, FGR, FLG, FLT3, FLT4, FRK, FYN, GAK, GRK1, GRK4, GRK7, GSK3A, GSK3B, HCK, HIPK3, ICK, IKBKE, INSRR, IRAK1, IRAK3, IRAK4, ITK, JAK2, JAK3, KARS, KDR, KIT, LATS1, LATS2, LCK, LRRK2, LTK, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K10, MAP3K11, MAP3K15, MAP3K19, MAP3K2, MAP3K7, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK12, MAPK15, MARK1, MARK2, MARK3, MARK4, MELK, MERTK, MINK1, MKNK2, MST1, MUSK, MYLK, MYLK2, NTRK1, NTRK2, NTRK3, NUAK1, NUAK2, PAK1, PAK2, PAK3, PAK4, PAK5, PAK6, PDGFRA, PDGFRB, PDK1, PDPK1, PF3D7_0217500, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIM1, PIM2, PIM3, PIP4K2B, PIP5K1A, PKD1, PKD2, PKN1, PKN2, PLK4, PRKAA1, PRKAA2, Prkaca, PRKACA, PRKACA, PRKACB, PRKACG, Prkca, PRKCA, Prkcb, PRKCB, Prkcd, PRKCD, Prkce, PRKCE, Prkcg, PRKCG, Prkch, PRKCH, PRKCI, Prkcq, PRKCQ, Prkcz, PRKCZ, PRKD1, PRKD2, PRKD3, PRKG1, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RET, RIOK3, ROCK1, ROCK2, ROS1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA5, RPS6KB1, SBK1, SBK3, SGK3, SIK1, SIK2, SIK3, SLK, SNRK, SRC, SRPK1, SRPK2, SRPK3, STK10, STK11, STK17A, STK17B, Stk3, STK3, STK32A, STK32B, STK33, STK38, STK38L, STK4, SYK, TAB1, TAOK1, TAOK2, TAOK3, TBK1, TIE1, TKT, TLK1, TLK2, TNIK, TNK1, TNK2, TSSK1B, TTK, TYK2, ULK1, ULK2, Ulk3, ULK3, YES1, ZAP70 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, ABL2, ACVR1, ACVR1B, AKT1, ANKK1, Blk, BMPR1B, BMX, BTK, CCNH, CDK14, CDK15, CDK18, CDK19, CDK8, CDKL1, CDKL2, CDKL5, CIT, CLK3, CSK, CSNK1A1L, CSNK1E, DCLK1, DYRK2, DYRK3, EGFR, EIF2AK2, EIF2AK3, EPHA1, EPHA2, EPHA4, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB4, FGFR2, FGFR4, FLT1, GCK, HIPK1, HIPK2, HIPK4, HUNK, IGF1R, IKBKB, INSR, LIMK1, MAP2K1, MAP3K1, MAP3K13, MAP3K5, MAP3K6, MAPK1, MAPK10, MAPK13, MAPK8, MAPK9, MAPKAPK2, MAPKAPK5, MAST1, MATK, MET, MKNK1, MST1R, MYLK3, MYLK4, MYO3A, MYO3B, NEK1, NEK2, NEK5, NIM1K, NLK, OSR1, OXSR1, PI4KB, PIK3C2G, PLK1, PLK2, PLK3, PRKAB1, PRKAB2, PRKCA, PRPF4B, PTK6, RIOK1, RIOK2, RIPK2, RIPK4, SGK1, SRC, SRMS, STK16, STK24, STK25, STK26, STK32C, STK35, STK39, TEK, TESK1, Tuba1a, TXK, TYRO3 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ACVR2A, ACVR2B, BMPR1A, BMPR2, CDKL3, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK2A1, CSNK2A2, CSNK2B, ERBB2, LIMK2, MAK, MAP3K12, MAP3K3, MAP3K4, MAPK3, MAPK6, MAPK7, MAPT, NEK11, NEK7, NEK8, NEK9, PIK3CG, PIP5K1C, RAF1, RPS6KA4, RPS6KA6, STK36, TEC, TERT, TGFBR1, TNNI3K, WEE1 |
10 (confirmed non-binding) |
Batch Information for HMSL10103-101-1:
HMS LINCS Batch ID: | 10103-101-1 |
Provider: | |
Provider Batch ID: | |
Salt: | 101 |
Molecular Formula: | |
Molecular Weight: | |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-12-02 |
(Kd <100 nM)