Gefitinib - Small Molecule (ID:10098-999)

HMS LINCS ID: 10098-999
Name: Gefitinib
Alternative Names: ZD1839; Iressa
LINCS ID: LSM-1098
PubChem CID: 123631
ChEBI ID:
ChEMBL ID:
Molecular Mass: 446.15
InChi: InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChi Key: XGALLCVXEZPNRQ-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
EGFR, GAK, IRAK1
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, CDK7, CHEK2, CSNK1E, EPHA6, ERBB2, ERBB3, ERBB4, HIPK4, IRAK4, LCK, LYN, MAP2K5, MAP3K19, MKNK1, MKNK2, RIPK2, SBK1, SLK, STK10, TPTEP2-CSNK1E, Tuba1a
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABCG2, ABL2, ACVR1, AKT1, AKT2, AXL, BCRP1, BLK, BRSK1, CAMK1, CAMK1D, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKK2, CDC7, CDK1, CDK2, CDK5, CDK8, CHEK1, CHUK, CIT, CLK2, CLK4, CSF1R, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DCLK3, DMPK, DYRK1A, DYRK1B, DYRK3, DYRK4, EEF2K, EPHA1, EPHA2, EPHA3, EPHA5, EPHA8, EPHB1, EPHB4, EPHB6, FES, FGFR1, FGR, FLG, FLT3, FLT4, FRK, GRK5, GSK3A, GSK3B, HCK, HIPK2, IKBKB, IKBKE, IRAK3, JAK3, KIT, LIMK1, LTK, MAP3K2, MAP3K3, MAP4K2, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK12, MAPK13, MAPK14, MAPK4, MAPK6, MAPK8, MAPK9, MAPKAPK2, MARK2, MARK3, MARK4, MATK, MET, MINK1, MST1R, MYLK2, NEK2, NEK4, NLK, NTRK2, NUAK2, PAK4, PASK, PDK1, PDPK1, PHKG1, PHKG2, PIM1, PIM3, PIP4K2C, PKD1, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, PRKD1, PRKD2, PRKD3, ROCK1, ROCK2, RPS6KA3, RPS6KA4, RPS6KB1, SGK2, SIK2, SRC, STK17A, STK17B, STK36, TAOK1, TBK1, TNIK, TNK2, TSSK2, TXK, Ulk3
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20161
Gefitinib KINOMEscan
 KINOMEscan
20266
Multiplexed imaging of protein levels and protein phosphorylation states in the MCF 10A breast cell line treated with nine kinase inhibitors
 Microscopy/Imaging

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10098-999-4
10098-999-5 Selleck Chemicals