Torin1 - Small Molecule (ID:10079-101)

HMS LINCS ID: 10079-101
Name: Torin1
Alternative Names:
LINCS ID: LSM-1079
PubChem CID: 49836027
ChEBI ID:
ChEMBL ID:
Molecular Mass: 607.22
InChi: InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3
InChi Key: AKCRNFFTGXBONI-UHFFFAOYSA-N
SMILES: CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
Mtor, MTOR, PRKDC
2
(equivalent to 100 nM ≤ Kd < 1µM)
GCK, MAP2K1, MAP2K1, MELK, MINK1, PIK3C2A, PIK3C2B, PIK3C3, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PIM1, PIM3
3
(equivalent to 1µM ≤ Kd < 10 µM)
PI4KB
10
(confirmed non-binding)
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Batch Information for HMSL10079-101-1:

HMS LINCS Batch ID: 10079-101-1
Provider: Nathanael Gray (DFCI)
Provider Batch ID: Torin1-1
Salt: 101
Molecular Formula: C35H28F3N5O2
Molecular Weight: 607.62
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10079-101-1:

Date HMS QC Outcome Comment Files
03/13/2015 PASS HMSL10079-101-1_LCMS.pdf