Barasertib - Small Molecule (ID:10067-101)

HMS LINCS ID: 10067-101
Name: Barasertib
Alternative Names: AZD1152-HQPA
LINCS ID: LSM-1067
PubChem CID: 16007391
ChEBI ID:
ChEMBL ID: 215152
Molecular Mass: 507.24
InChi: InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33)
InChi Key: QYZOGCMHVIGURT-UHFFFAOYSA-N
SMILES: CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AIM1, AURKB, AURKC, EPHB6, HIPK4, KIT, MAP2K5, PDGFRA, PDGFRB
2
(equivalent to 100 nM ≤ Kd < 1µM)
AURKA, AXL, ERBB4, FLT1, FLT3, KDR, LCK, MAP3K7, MAP4K5, RET, TIE1, Tuba1a
3
(equivalent to 1µM ≤ Kd < 10 µM)
AAK1, ABL1, ANKK1, BLK, BTK, CDK1, CDK11A, CDK11B, CDK13, CDK16, CDK7, CDKL2, CHEK2, CHUK, CIT, CSF1R, CSK, CSNK1A1, DDR1, DDR2, DSTYK, DYRK1A, EGFR, EIF2AK1, ERBB2, FLT4, GRK5, HCK, HIPK2, HIPK3, IRAK3, LTK, LYN, MAP2K1, MAP2K2, MAP3K19, MAP3K20, MAP4K2, MAPK13, MET, MKNK2, MST1R, MUSK, PLK4, PRKCG, PRKCZ, RIPK2, ROCK1, ROCK2, RPS6KB1, SRMS, STK10, STK36, TAOK1, TBK1, TEK, TKT, TNIK, TTK, YES1
10
(confirmed non-binding)
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Batch Information for HMSL10067-101-1:

HMS LINCS Batch ID: 10067-101-1
Provider: Axon Medchem
Provider Batch ID: 1580-1
Salt: 101
Molecular Formula: C26H30FN7O3
Molecular Weight: 507.56
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04