Barasertib - Small Molecule (ID:10067-101)
HMS LINCS ID: | 10067-101 |
Name: | Barasertib |
Alternative Names: | AZD1152-HQPA |
LINCS ID: | LSM-1067 |
PubChem CID: | 16007391 |
ChEBI ID: | |
ChEMBL ID: | 215152 |
Molecular Mass: | 507.24 |
InChi: | InChI=1S/C26H30FN7O3/c1-2-34(10-11-35)9-4-12-37-21-7-8-22-23(16-21)28-17-29-26(22)31-24-14-20(32-33-24)15-25(36)30-19-6-3-5-18(27)13-19/h3,5-8,13-14,16-17,35H,2,4,9-12,15H2,1H3,(H,30,36)(H2,28,29,31,32,33) |
InChi Key: | QYZOGCMHVIGURT-UHFFFAOYSA-N |
SMILES: | CCN(CCCOC1=CC2=C(C=C1)C(=NC=N2)NC3=NNC(=C3)CC(=O)NC4=CC(=CC=C4)F)CCO |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
AIM1, AURKB, AURKC, EPHB6, HIPK4, KIT, MAP2K5, PDGFRA, PDGFRB | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AURKA, AXL, ERBB4, FLT1, FLT3, KDR, LCK, MAP3K7, MAP4K5, RET, TIE1, Tuba1a |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AAK1, ABL1, ANKK1, BLK, BTK, CDK1, CDK11A, CDK11B, CDK13, CDK16, CDK7, CDKL2, CHEK2, CHUK, CIT, CSF1R, CSK, CSNK1A1, DDR1, DDR2, DSTYK, DYRK1A, EGFR, EIF2AK1, ERBB2, FLT4, GRK5, HCK, HIPK2, HIPK3, IRAK3, LTK, LYN, MAP2K1, MAP2K2, MAP3K19, MAP3K20, MAP4K2, MAPK13, MET, MKNK2, MST1R, MUSK, PLK4, PRKCG, PRKCZ, RIPK2, ROCK1, ROCK2, RPS6KB1, SRMS, STK10, STK36, TAOK1, TBK1, TEK, TKT, TNIK, TTK, YES1 |
10 (confirmed non-binding) |
Batch Information for HMSL10067-101-1:
HMS LINCS Batch ID: | 10067-101-1 |
Provider: | Axon Medchem |
Provider Batch ID: | 1580-1 |
Salt: | 101 |
Molecular Formula: | C26H30FN7O3 |
Molecular Weight: | 507.56 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
(Kd <100 nM)