GSK1070916 - Small Molecule (ID:10062-101)

HMS LINCS ID: 10062-101
Name: GSK1070916
Alternative Names: KIN001-216
LINCS ID: LSM-1062
PubChem CID: 46885626
ChEBI ID:
ChEMBL ID: 1090479
Molecular Mass: 507.27
InChi: InChI=1S/C30H33N7O/c1-6-37-19-26(28(34-37)21-10-12-23(13-11-21)32-30(38)36(4)5)24-14-15-31-29-25(24)17-27(33-29)22-9-7-8-20(16-22)18-35(2)3/h7-17,19H,6,18H2,1-5H3,(H,31,33)(H,32,38)
InChi Key: QTBWCSQGBMPECM-UHFFFAOYSA-N
SMILES: CCN1C=C(C(=N1)C2=CC=C(C=C2)NC(=O)N(C)C)C3=C4C=C(NC4=NC=C3)C5=CC(=CC=C5)CN(C)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-04-04

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
AIM1, AURKB, AURKC, FGFR1, FLG, FLT1, FLT4, SIK1, TEK
2
(equivalent to 100 nM ≤ Kd < 1µM)
AURKA

Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20003
Tang Mitosis/Apoptosis ver. II
Microscopy/Imaging
20120
Metrics other than potency reveal systematic variation in responses to cancer drugs
Analysis
20268
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates.
Analysis
20269
Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics.
Analysis
20270
Growth rate-corrected (GR) dose-response metric signatures across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 3 of 4: Median, upper quartile, and lower quartile GR metrics per perturbagen.
Analysis

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10062-101-1 Haoyuan chemexpress HM-040_11-20100714
10062-101-2 Haoyuan Chemexpress HM-040_TM-20100709
10062-101-3