TAK-715 - Small Molecule (ID:10060-101)
HMS LINCS ID: | 10060-101 |
Name: | TAK-715 |
Alternative Names: | |
LINCS ID: | LSM-1060 |
PubChem CID: | 9952773 |
ChEBI ID: | |
ChEMBL ID: | |
Molecular Mass: | 399.14 |
InChi: | InChI=1S/C24H21N3OS/c1-3-21-27-22(18-11-7-8-16(2)14-18)23(29-21)19-12-13-25-20(15-19)26-24(28)17-9-5-4-6-10-17/h4-15H,3H2,1-2H3,(H,25,26,28) |
InChi Key: | HEKAIDKUDLCBRU-UHFFFAOYSA-N |
SMILES: | CCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
CSNK1D, MAP4K4, MAPK14 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, CSNK1A1, CSNK1E, CSNK1G1, EGFR, ERBB4, FLT1, FLT4, FRK, FYN, KDR, MAPK10, MAPK11, MAPK9, MINK1, PRKD3, PTK6, TPTEP2-CSNK1E |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AXL, BLK, BTK, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CHEK1, CHEK2, CHUK, CLK2, CSF1R, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK3, DYRK4, EEF2K, EPHA2, ERBB2, FER, FES, FGFR1, FGFR3, FLG, FLT3, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, JAK3, KIT, LCK, LYN, MAP4K2, MAP4K5, MAPK1, MAPK12, MAPK13, MAPK8, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, PRKD2, PRKG1, PRKG2, PRKX, PTK2, PTK2B, RET, ROCK2, ROS1, RPS6KA3, RPS6KA5, RPS6KB1, SLK, SRC, SRMS, SRPK1, STK17A, STK3, SYK, TSSK1B, TSSK2, TYK2, TYRO3 |
10 (confirmed non-binding) |
Batch Information for HMSL10060-101-1:
HMS LINCS Batch ID: | 10060-101-1 |
Provider: | Haoyuan chemexpress |
Provider Batch ID: | HY-999-20110107 |
Salt: | 101 |
Molecular Formula: | C24H21N3OS |
Molecular Weight: | 399.51 |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2011-07-15 |
Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10060-101-1:
Date | HMS QC Outcome | Comment | Files |
---|---|---|---|
03/13/2015 | PASS | HMSL10060-101-1_LCMS.pdf | |
02/22/2011 | PASS | None |
(Kd <100 nM)