Lapatinib - Small Molecule (ID:10051-999)
HMS LINCS ID: | 10051-999 |
Name: | Lapatinib |
Alternative Names: | GW-572016; Tykerb |
LINCS ID: | LSM-1051 |
PubChem CID: | 208908 |
ChEBI ID: | |
ChEMBL ID: | 554 |
Molecular Mass: | 580.13 |
InChi: | InChI=1S/C29H26ClFN4O4S/c1-40(36,37)12-11-32-16-23-7-10-27(39-23)20-5-8-26-24(14-20)29(34-18-33-26)35-22-6-9-28(25(30)15-22)38-17-19-3-2-4-21(31)13-19/h2-10,13-15,18,32H,11-12,16-17H2,1H3,(H,33,34,35) |
InChi Key: | BCFGMOOMADDAQU-UHFFFAOYSA-N |
SMILES: | CS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl |
Relevant Citations: | |
Comments: | |
Date Publicly Available: | |
Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)Target Affinity Spectrum Value | HUGO Gene Name |
---|---|
EGFR, ERBB2, ERBB4, Tuba1a | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | PI4KB, PIK3C2B, RAF1 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | CDC7, CDK1, CHEK2, CHUK, CSNK1A1, DYRK1A, DYRK3, DYRK4, EEF2K, ERBB3, GRK5, HIPK2, HIPK4, IKBKB, IRAK1, MAP2K5, MAP2K7, MAP4K2, MAPK13, MATK, MINK1, MST1R, NEK4, PASK, PIK3C2G, PRKCG, PRKCI, PRKCZ, RIPK2, ROCK1, ROCK2, RPS6KB1, SLK, STK10, TAOK1, TBK1, TSSK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10051-999-3:
HMS LINCS Batch ID: | 10051-999-3 |
Provider: | |
Provider Batch ID: | |
Salt: | 999 |
Molecular Formula: | |
Molecular Weight: | |
Purity: | |
Purification Method: | |
Chemical Synthesis Reference: | |
Comments: | |
Date Publicly Available: | 2012-11-14 |
Most Recent Update: | 2016-12-02 |
(Kd <100 nM)