Pictilisib - Small Molecule (ID:10047-101)
| HMS LINCS ID: |
10047-101
|
| Name: | Pictilisib |
| Alternative Names: | Pictrelisib; GDC-0941; RG-7321 |
| LINCS ID: | LSM-1047 |
| PubChem CID: | 17755052 |
| ChEBI ID: | |
| ChEMBL ID: | 521851 |
| Molecular Mass: | 513.16 |
| InChi: | InChI=1S/C23H27N7O3S2/c1-35(31,32)30-7-5-28(6-8-30)15-16-13-20-21(34-16)23(29-9-11-33-12-10-29)26-22(25-20)17-3-2-4-19-18(17)14-24-27-19/h2-4,13-14H,5-12,15H2,1H3,(H,24,27) |
| InChi Key: | LHNIIDJUOCFXAP-UHFFFAOYSA-N |
| SMILES: | CS(=O)(=O)N1CCN(CC1)CC2=CC3=C(S2)C(=NC(=N3)C4=C5C=NNC5=CC=C4)N6CCOCC6 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-12-20 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AKT1, PIK3CA, PIK3CB, PIK3CD, PIK3CG | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CLK2, HIPK2, HIPK3, JAK1, MAPK10, MTOR, MYLK4, PDGFRA, PIK3C2B, PIK3C2G, RIOK2 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AAK1, CAMK1, CAMK1G, CDK16, CDK18, CDK7, CLK1, CLK4, CSNK1D, CSNK1E, CSNK2A2, DAPK1, DAPK3, DYRK1B, DYRK2, EPHB6, FLT3, GAK, HIPK1, HIPK4, ICK, IRAK3, MAP3K19, MAPK8, MAPK9, MELK, NTRK1, PLK4, PRKDC, RPS6KA3, RPS6KA6, STK16, TPTEP2-CSNK1E, TTK, TYK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10047-101-4:
| HMS LINCS Batch ID: | 10047-101-4 |
| Provider: | Selleck Chemicals |
| Provider Batch ID: | |
| Salt: | 101 |
| Molecular Formula: | C23H27N7O3S2 |
| Molecular Weight: | 513.64 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-12-22 |
| Most Recent Update: | 2016-12-22 |
(Kd <100 nM)