Motesanib - Small Molecule (ID:10042-999)

HMS LINCS ID: 10042-999
Name: Motesanib
Alternative Names: AMG706
LINCS ID: LSM-1042
PubChem CID: 11667893
ChEBI ID:
ChEMBL ID:
Molecular Mass: 373.19
InChi: InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28)
InChi Key: RAHBGWKEPAQNFF-UHFFFAOYSA-N
SMILES: CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CSF1R, FLT1, FLT4, FRK, KDR, KIT, MAP3K20, PDGFRA, PDGFRB, RET
2
(equivalent to 100 nM ≤ Kd < 1µM)
BRAF, CIT, DDR1, EPHA6, FPGT-TNNI3K, LCK, LYN, MAP3K19, RAF1, TNNI3K
3
(equivalent to 1µM ≤ Kd < 10 µM)
ABL1, ABL2, AURKC, BLK, EGFR, EIF2AK4, FGFR1, FGFR4, FGR, FLG, FLT3, FYN, HCK, JAK1, MAP3K2, MAP3K3, MAP3K7, MAP4K4, PTK6, RIPK2, SLK, STK10, STK35, YES1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20150
AMG-706 KINOMEscan
KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10042-999-2