Motesanib - Small Molecule (ID:10042-999)
| HMS LINCS ID: |
10042-999
|
| Name: | Motesanib |
| Alternative Names: | AMG706 |
| LINCS ID: | LSM-1042 |
| PubChem CID: | 11667893 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 373.19 |
| InChi: | InChI=1S/C22H23N5O/c1-22(2)14-26-19-12-16(5-6-18(19)22)27-21(28)17-4-3-9-24-20(17)25-13-15-7-10-23-11-8-15/h3-12,26H,13-14H2,1-2H3,(H,24,25)(H,27,28) |
| InChi Key: | RAHBGWKEPAQNFF-UHFFFAOYSA-N |
| SMILES: | CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-07-12 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
CSF1R, FLT1, FLT4, FRK, KDR, KIT, MAP3K20, PDGFRA, PDGFRB, RET | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | BRAF, CIT, DDR1, EPHA6, FPGT-TNNI3K, LCK, LYN, MAP3K19, RAF1, TNNI3K |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ABL1, ABL2, AURKC, BLK, EGFR, EIF2AK4, FGFR1, FGFR4, FGR, FLG, FLT3, FYN, HCK, JAK1, MAP3K2, MAP3K3, MAP3K7, MAP4K4, PTK6, RIPK2, SLK, STK10, STK35, YES1 |
10 (confirmed non-binding) |
Batch Information for HMSL10042-999-2:
| HMS LINCS Batch ID: | 10042-999-2 |
| Provider: | |
| Provider Batch ID: | |
| Salt: | 999 |
| Molecular Formula: | |
| Molecular Weight: | |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-05-27 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)