SB 239063 - Small Molecule (ID:10036-101)

HMS LINCS ID: 10036-101
Name: SB 239063
Alternative Names:
LINCS ID: LSM-44951
PubChem CID: 5166
ChEBI ID:
ChEMBL ID:
Molecular Mass: 368.16
InChi: InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3
InChi Key: ZQUSFAUAYSEREK-UHFFFAOYSA-N
SMILES: COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2018-03-30

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
CSNK1D, MAP2K2, MAP4K4, MAPK11, MAPK14, PRKCA
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, CSNK1A1, FLT1, FRK, FYN, LCK, MAP4K5, MAPK9, MINK1
3
(equivalent to 1µM ≤ Kd < 10 µM)
AIM1, AKT1, AKT2, ALK, AURKA, AURKB, AXL, BLK, BTK, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CHEK1, CHEK2, CHUK, CLK2, CSF1R, CSNK1G1, CSNK1G2, CSNK1G3, CSNK2A1, DAPK3, DYRK1A, DYRK3, DYRK4, EEF2K, EGFR, EPHA2, ERBB2, ERBB4, FER, FES, FGFR1, FGFR3, FLG, FLT3, FLT4, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, JAK3, KDR, KIT, LYN, MAP4K2, MAPK1, MAPK8, MAPKAPK2, MAPKAPK5, MARK2, MARK3, MATK, MELK, MET, NEK4, NTRK1, NTRK2, NTRK3, PAK4, PDK1, PDPK1, PHKG2, PIM2, PIM3, PKD2, PKN2, PLK1, PLK3, PLK4, PRKAA1, PRKACA, PRKCD, PRKCG, PRKCI, PRKCZ, PRKD2, PRKD3, PRKG1, PRKG2, PRKX, PTK2, PTK2B, PTK6, RET, ROCK2, ROS1, RPS6KA3, RPS6KA5, RPS6KB1, SRC, SRMS, SRPK1, STK17A, STK3, SYK, TSSK1B, TSSK2, TYK2, TYRO3
10
(confirmed non-binding)
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Batch Information for HMSL10036-101-1:

HMS LINCS Batch ID: 10036-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-999-20090617
Salt: 101
Molecular Formula: C20H21FN4O2
Molecular Weight: 368.4
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10036-101-1:

Date HMS QC Outcome Comment Files
03/13/2015 PASS HMSL10036-101-1_LCMS.pdf
02/22/2011 PASS None