Sigma A6730 - Small Molecule (ID:10035-109)
| HMS LINCS ID: |
10035-109
|
| Name: | Sigma A6730 |
| Alternative Names: | KIN001-102; AKT inhibitor VIII; Akt1/2 kinase inhibitor |
| LINCS ID: | LSM-1035 |
| PubChem CID: | 10196499 |
| ChEBI ID: | |
| ChEMBL ID: | 258844 |
| Molecular Mass: | 551.24 |
| InChi: | InChI=1S/C34H29N7O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42) |
| InChi Key: | BIWGYFZAEWGBAL-UHFFFAOYSA-N |
| SMILES: | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
AKT1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | AKT2, CAMK1, MYLK |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AKT3 |
10 (confirmed non-binding) |
Batch Information for HMSL10035-109-4:
| HMS LINCS Batch ID: | 10035-109-4 |
| Provider: | Sigma-Aldrich |
| Provider Batch ID: | |
| Salt: | 109 |
| Molecular Formula: | C34H29N7O.xC2HF3O2.yH2O |
| Molecular Weight: | |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-06-26 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)