Saracatinib - Small Molecule (ID:10032-101)
| HMS LINCS ID: |
10032-101
|
| Name: | Saracatinib |
| Alternative Names: | AZD0530 |
| LINCS ID: | LSM-1032 |
| PubChem CID: | 10302451 |
| ChEBI ID: | |
| ChEMBL ID: | 217092 |
| Molecular Mass: | 541.21 |
| InChi: | InChI=1S/C27H32ClN5O5/c1-32-6-8-33(9-7-32)10-13-35-19-14-21-24(23(15-19)38-18-4-11-34-12-5-18)27(30-16-29-21)31-25-20(28)2-3-22-26(25)37-17-36-22/h2-3,14-16,18H,4-13,17H2,1H3,(H,29,30,31) |
| InChi Key: | OUKYUETWWIPKQR-UHFFFAOYSA-N |
| SMILES: | CN1CCN(CC1)CCOC2=CC(=C3C(=C2)N=CN=C3NC4=C(C=CC5=C4OCO5)Cl)OC6CCOCC6 |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-04-04 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
ABL1, LCK, SRC, YES1 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | CSK, KIT |
3 (equivalent to 1µM ≤ Kd < 10 µM) | EGFR, PDGFRB |
10 (confirmed non-binding) |
Batch Information for HMSL10032-101-3:
| HMS LINCS Batch ID: | 10032-101-3 |
| Provider: | MedChem Express |
| Provider Batch ID: | 04963 |
| Salt: | 101 |
| Molecular Formula: | C27H32ClN5O5 |
| Molecular Weight: | 542.03 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2015-06-17 |
| Most Recent Update: | 2016-04-04 |
HMS QC Testing Events for HMSL10032-101-3:
| Date | HMS QC Outcome | Comment | Files |
|---|---|---|---|
| 08/31/2015 | PASS | HMSL10032-101-3_LCMS.pdf |
(Kd <100 nM)