Dasatinib - Small Molecule (ID:10020-999)

HMS LINCS ID: 10020-999
Name: Dasatinib
Alternative Names: BMS-354825; Sprycel
LINCS ID: LSM-1020
PubChem CID: 3062316
ChEBI ID:
ChEMBL ID: 1421
Molecular Mass: 487.16
InChi: InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)
InChi Key: ZBNZXTGUTAYRHI-UHFFFAOYSA-N
SMILES: CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-07-12

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ABL1, ABL2, BCR, Blk, BLK, BMPR1B, BMX, BTK, CSF1R, CSK, DDR1, DDR2, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, ERBB3, ERBB4, FGR, FPGT-TNNI3K, FRK, FYN, GAK, HCK, KIT, Lck, LCK, LIMK2, LYN, MAP2K5, MAP3K19, MAP3K20, MAP4K5, MAPK14, PDGFRA, PDGFRB, PTK6, RIPK2, SIK1, SIK1B, SIK2, SIK3, SRC, SRC, SRMS, TEC, TESK1, TKT, TNK2, TNNI3K, Tuba1a, TXK, YES1
2
(equivalent to 100 nM ≤ Kd < 1µM)
ACVR1, ACVR1B, ACVR2A, ACVR2B, ACVRL1, BRAF, COQ8A, EGFR, ERBB2, JAK3, LIMK1, MAP3K2, MAP3K3, MAP3K4, MAP4K1, MAP4K3, MAPK11, MINK1, MYT1, NEK11, NLK, PF3D7_0217500, PKMYT1, RAF1, RET, SLK, STK35, STK36, TGFBR1, TYK2, WEE2
3
(equivalent to 1µM ≤ Kd < 10 µM)
AIM1, AURKA, AURKB, BMPR1A, CDC42BPA, CDC42BPB, CDC42BPG, CDC7, CDK1, CDK2, CHEK2, CHUK, CSNK1A1, CSNK1E, DMPK, DYRK1A, DYRK3, DYRK4, EEF2K, EIF2AK4, EPHA6, FGFR1, FGFR2, FGFR3, FLG, FLT1, FLT3, GRK5, HIPK2, HIPK4, IKBKB, IRAK1, IRAK4, JAK2, KDR, MAP2K1, MAP2K2, MAP3K13, MAP3K7, MAP4K2, MAP4K4, MAPK12, MAPK13, MATK, MST1, MST1R, MYLK2, NEK2, NEK4, PRKCG, PRKCI, ROCK1, ROCK2, RPS6KB1, SBK1, SGK2, STK10, STK25, STK26, STK4, SYK, TAOK1, TAOK2, TAOK3, TBK1, TGFBR2, TNIK, TPTEP2-CSNK1E, TSSK2, ULK3, VRK2, WEE1
10
(confirmed non-binding)
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Datasets:

HMS Dataset ID Dataset Title HMS Dataset Type
20000
Target Affinity Spectrum (TAS) vectors for compounds in the HMS LINCS small molecule library.
Analysis
20196
Dasatinib KINOMEscan
 KINOMEscan

Batch Information:

HMS LINCS Batch ID Provider Provider Batch ID
10020-999-3