GW843682X - Small Molecule (ID:10014-101)
| HMS LINCS ID: |
10014-101
|
| Name: | GW843682X |
| Alternative Names: | GW843682 |
| LINCS ID: | LSM-1014 |
| PubChem CID: | 9826308 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 477.10 |
| InChi: | InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29) |
| InChi Key: | JSKUWFIZUALZLX-UHFFFAOYSA-N |
| SMILES: | COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-09 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
FLT3, FLT4, MAPKAPK5, PLK1, PLK3, SLK, TSSK2 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | ABL1, AXL, BRSK1, CLK4, CSF1R, FLT1, FYN, JAK3, KDR, KIT, MAP4K4, MAP4K5, MELK, NEK2, NTRK1, PDGFRB, PLK4, PRKG1, PTK2, PTK2B, RPS6KA5, STK10, STK3, TSSK1B |
3 (equivalent to 1µM ≤ Kd < 10 µM) | AIM1, AKT1, AKT2, AURKA, AURKB, BLK, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CHEK2, CHUK, CLK2, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, DAPK3, DYRK1A, DYRK3, EEF2K, EPHA2, ERBB2, ERBB4, FGFR1, FGFR3, FLG, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, LCK, LIMK1, LYN, MAP4K2, MAPK1, MAPK12, MAPK13, MAPK8, MAPK9, MAPKAPK2, MARK2, MARK3, MET, MINK1, NEK4, NTRK2, PAK4, PASK, PDK1, PDPK1, PHKG2, PIM2, PKN2, PRKAA1, PRKACA, PRKCG, PRKCZ, PRKG2, PRKX, ROCK2, RPS6KA3, RPS6KB1, SRPK1, TYK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10014-101-3:
| HMS LINCS Batch ID: | 10014-101-3 |
| Provider: | Sigma-Aldrich |
| Provider Batch ID: | |
| Salt: | 101 |
| Molecular Formula: | C22H18F3N3O4S |
| Molecular Weight: | 477.46 |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-05-06 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)