GW843682X - Small Molecule (ID:10014-101)

HMS LINCS ID: 10014-101
Name: GW843682X
Alternative Names: GW843682
LINCS ID: LSM-1014
PubChem CID: 9826308
ChEBI ID:
ChEMBL ID:
Molecular Mass: 477.10
InChi: InChI=1S/C22H18F3N3O4S/c1-30-16-7-14-15(8-17(16)31-2)28(11-27-14)19-9-18(20(33-19)21(26)29)32-10-12-5-3-4-6-13(12)22(23,24)25/h3-9,11H,10H2,1-2H3,(H2,26,29)
InChi Key: JSKUWFIZUALZLX-UHFFFAOYSA-N
SMILES: COC1=C(C=C2C(=C1)N=CN2C3=CC(=C(S3)C(=O)N)OCC4=CC=CC=C4C(F)(F)F)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-09

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
FLT3, FLT4, MAPKAPK5, PLK1, PLK3, SLK, TSSK2
2
(equivalent to 100 nM ≤ Kd < 1µM)
ABL1, AXL, BRSK1, CLK4, CSF1R, FLT1, FYN, JAK3, KDR, KIT, MAP4K4, MAP4K5, MELK, NEK2, NTRK1, PDGFRB, PLK4, PRKG1, PTK2, PTK2B, RPS6KA5, STK10, STK3, TSSK1B
3
(equivalent to 1µM ≤ Kd < 10 µM)
AIM1, AKT1, AKT2, AURKA, AURKB, BLK, CAMK1, CAMK2B, CAMK2D, CAMK2G, CDC7, CDK1, CDK2, CHEK2, CHUK, CLK2, CSNK1A1, CSNK1D, CSNK1G1, CSNK1G2, DAPK3, DYRK1A, DYRK3, EEF2K, EPHA2, ERBB2, ERBB4, FGFR1, FGFR3, FLG, GSK3A, GSK3B, HIPK2, HIPK4, IGF1R, IKBKB, INSR, IRAK1, ITK, JAK2, LCK, LIMK1, LYN, MAP4K2, MAPK1, MAPK12, MAPK13, MAPK8, MAPK9, MAPKAPK2, MARK2, MARK3, MET, MINK1, NEK4, NTRK2, PAK4, PASK, PDK1, PDPK1, PHKG2, PIM2, PKN2, PRKAA1, PRKACA, PRKCG, PRKCZ, PRKG2, PRKX, ROCK2, RPS6KA3, RPS6KB1, SRPK1, TYK2
10
(confirmed non-binding)
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Batch Information for HMSL10014-101-1:

HMS LINCS Batch ID: 10014-101-1
Provider: Haoyuan chemexpress
Provider Batch ID: HY-999-20101020
Salt: 101
Molecular Formula: C22H18F3N3O4S
Molecular Weight: 477.46
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2011-07-15
Most Recent Update: 2016-04-04

HMS QC Testing Events for HMSL10014-101-1:

Date HMS QC Outcome Comment Files
03/13/2015 PASS HMSL10014-101-1_LCMS.pdf
02/22/2011 PASS None