GSK461364 - Small Molecule (ID:10013-999)
| HMS LINCS ID: |
10013-999
|
| Name: | GSK461364 |
| Alternative Names: | GSK461364A |
| LINCS ID: | LSM-1013 |
| PubChem CID: | 15983966 |
| ChEBI ID: | |
| ChEMBL ID: | |
| Molecular Mass: | 543.19 |
| InChi: | InChI=1S/C27H28F3N5O2S/c1-17(19-5-3-4-6-20(19)27(28,29)30)37-23-14-24(38-25(23)26(31)36)35-16-32-21-8-7-18(13-22(21)35)15-34-11-9-33(2)10-12-34/h3-8,13-14,16-17H,9-12,15H2,1-2H3,(H2,31,36)/t17-/m1/s1 |
| InChi Key: | ZHJGWYRLJUCMRT-QGZVFWFLSA-N |
| SMILES: | C[C@H](C1=CC=CC=C1C(F)(F)F)OC2=C(SC(=C2)N3C=NC4=C3C=C(C=C4)CN5CCN(CC5)C)C(=O)N |
| Relevant Citations: | |
| Comments: | |
| Date Publicly Available: | |
| Most Recent Update: | 2016-05-06 |
Target Affinity:
(see Study 20000)| Target Affinity Spectrum Value | HUGO Gene Name |
|---|---|
NUAK2, PLK1, STK10 | |
2 (equivalent to 100 nM ≤ Kd < 1µM) | BMP2K, CAMK2D, CSNK2A2, FLT3, NEK2, PIM1, PIP5K1A, PKN2, PLK2, PLK3, RPS6KA3, RPS6KA4, RPS6KA6 |
3 (equivalent to 1µM ≤ Kd < 10 µM) | ANKK1, BRSK2, CAMK2A, CAMK2B, CAMK2G, CDK7, CSNK2A1, DAPK1, DAPK2, DAPK3, EIF2AK4, GRK4, GRK7, IRAK1, IRAK3, KIT, MAP3K1, MAP3K19, MAP3K9, MAP4K2, MERTK, NEK1, NEK5, NEK8, NEK9, NIM1K, PDGFRB, PIK3C2B, PIK3CB, PIK3CD, PIK3CG, PIM3, PIP4K2B, PIP5K1C, PRKCD, PRKCI, PRKD3, RIOK1, RIOK3, ROCK1, RPS6KA2, SLK, SRPK3, TAOK3, TIE1, ULK2 |
10 (confirmed non-binding) |
Batch Information for HMSL10013-999-4:
| HMS LINCS Batch ID: | 10013-999-4 |
| Provider: | |
| Provider Batch ID: | |
| Salt: | 999 |
| Molecular Formula: | |
| Molecular Weight: | |
| Purity: | |
| Purification Method: | |
| Chemical Synthesis Reference: | |
| Comments: | |
| Date Publicly Available: | 2016-05-27 |
| Most Recent Update: | 2016-12-02 |
(Kd <100 nM)