Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line Drug name Experimental replicate Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared curve fit (GR values) P-value curve fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared curve fit (relative cell counts) P-value curve fit (relative cell counts)
HCC1806 QL-VIII-58 1
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 1
 9 2.619
0.471
-0.657
0.441
1.51
-0.961
0.923
0.997
8.08e-44
0.388
0.00996
0.645
0.388
0.0
1.08
0.993
3.33e-37
HCC1806 QL-VIII-58 2
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 2
 9 2.714
0.377
-0.671
0.481
1.56
-1.0
0.773
0.938
2.91e-21
0.267
0.00748
0.596
0.267
0.0
0.778
0.895
2.46e-17
HCC1806 QL-VIII-58 3
sigmoid
sigmoid
HCC1806 QL-VIII-58 0 3
 9 2.697
0.386
-0.758
0.491
1.25
-1.0
0.936
0.991
1.99e-35
0.289
0.00336
0.612
0.289
0.0
1.04
0.987
8.61e-33
HCC1806 QL-X-138 1
sigmoid
sigmoid
HCC1806 QL-X-138 0 1
 9 2.619
6.42
0.243
0.0784
13.0
-0.855
1.41
0.992
2.35e-36
5.79
0.288
0.918
5.79
0.0
1.63
0.987
1.31e-32
HCC1806 QL-X-138 2
sigmoid
sigmoid
HCC1806 QL-X-138 0 2
 9 2.714
6.65
0.278
0.084
15.6
-1.0
1.29
0.989
2.34e-34
5.77
0.297
0.907
5.77
0.0
1.52
0.982
3.19e-30
HCC1806 QL-X-138 3
sigmoid
sigmoid
HCC1806 QL-X-138 0 3
 9 2.697
6.59
0.283
0.0757
10.6
-0.493
1.46
0.982
2.01e-30
5.91
0.302
0.919
5.91
0.0
1.58
0.969
2.38e-26
HCC1806 QL-XII-108 1
sigmoid
sigmoid
HCC1806 QL-XII-108 0 1
 9 2.619
7.21
0.374
0.081
12.1
-0.403
1.15
0.986
2.16e-32
6.53
0.374
0.911
6.53
0.0
1.2
0.979
2.47e-29
HCC1806 QL-XII-108 2
sigmoid
sigmoid
HCC1806 QL-XII-108 0 2
 9 2.714
6.59
0.385
0.105
5.93
0.0605
1.22
0.87
9.22e-16
5.58
0.369
0.88
4.06
0.163
1.24
0.847
1.36e-14
HCC1806 QL-XII-108 3
sigmoid
sigmoid
HCC1806 QL-XII-108 0 3
 9 2.697
4.76
0.208
0.11
5.85
-0.166
1.39
0.964
2.49e-25
4.23
0.262
0.882
3.69
0.0906
1.46
0.97
1.09e-26
HCC1806 QL-XII-47 1
sigmoid
sigmoid
HCC1806 QL-XII-47 0 1
 9 2.619
1.16
-0.581
0.307
1.74
-0.626
2.01
0.998
7.86e-47
1.09
0.0168
0.766
1.07
0.0132
2.48
0.995
5.29e-40
HCC1806 QL-XII-47 2
sigmoid
sigmoid
HCC1806 QL-XII-47 0 2
 9 2.714
0.868
-0.549
0.348
1.26
-0.554
1.99
0.988
2.69e-33
0.834
0.0177
0.73
0.818
0.0268
2.94
0.984
2.66e-31
HCC1806 QL-XII-47 3
sigmoid
sigmoid
HCC1806 QL-XII-47 0 3
 9 2.697
0.895
-0.767
0.363
1.51
-0.807
1.85
0.996
8.24e-41
0.849
0.00316
0.74
0.843
0.011
3.09
0.991
6.37e-36
HCC1806 QL-XII-61 1
sigmoid
sigmoid
HCC1806 QL-XII-61 0 1
 9 2.619
6.9
0.407
0.0291
5.14
0.386
5.0
0.962
5.78e-25
6.52
0.4
0.974
4.87
0.384
5.0
0.956
8.68e-24
HCC1806 QL-XII-61 2
sigmoid
sigmoid
HCC1806 QL-XII-61 0 2
 9 2.714
5.89
0.373
0.0452
4.56
0.36
5.0
0.979
1.48e-27
5.48
0.361
0.953
4.3
0.352
5.0
0.971
2.71e-25
HCC1806 QL-XII-61 3
sigmoid
sigmoid
HCC1806 QL-XII-61 0 3
 9 2.697
5.77
0.315
0.0462
4.81
0.298
5.0
0.976
3.4e-28
5.48
0.324
0.954
4.51
0.311
5.0
0.961
1.27e-24
HCC1806 Torin1 1
sigmoid
sigmoid
HCC1806 Torin1 0 1
 9 2.619
0.515
0.179
0.326
0.302
0.148
0.662
0.971
9.22e-27
0.347
0.251
0.66
0.129
0.272
0.796
0.975
8.08e-28
HCC1806 Torin1 2
sigmoid
sigmoid
HCC1806 Torin1 0 2
 9 2.714
0.669
0.197
0.315
0.434
0.115
0.604
0.978
7.13e-29
0.411
0.249
0.661
0.161
0.243
0.708
0.978
9.2e-29
HCC1806 Torin1 3
sigmoid
sigmoid
HCC1806 Torin1 0 3
 9 2.697
0.393
0.144
0.339
0.25
0.145
0.753
0.972
4.9e-27
0.243
0.222
0.648
0.112
0.264
0.964
0.972
5.22e-27
HCC1806 Torin2 1
sigmoid
sigmoid
HCC1806 Torin2 0 1
 9 2.619
0.0655
-0.43
0.683
0.107
-0.389
1.17
0.994
7.49e-39
0.0584
0.0375
0.456
0.0546
0.0391
1.2
0.997
3.89e-44
HCC1806 Torin2 2
sigmoid
sigmoid
HCC1806 Torin2 0 2
 9 2.714
0.0767
-0.467
0.658
0.13
-0.401
1.12
0.99
2.21e-34
0.0654
0.0278
0.465
0.062
0.0296
1.13
0.994
4.16e-38
HCC1806 Torin2 3
sigmoid
sigmoid
HCC1806 Torin2 0 3
 9 2.697
0.06
-0.564
0.7
0.119
-0.475
0.977
0.987
4.74e-33
0.0508
0.0164
0.441
0.0481
0.0316
1.17
0.993
3.18e-37