Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset - HMS LINCS Database

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)

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Cell line	Drug name	Experimental replicate	Curve type (GR values)	Curve type (relative cell counts)	Experiment name	Number of concentrations	Cell doublings (DMSO control)	GR50	GRmax	GR_AOC	GEC50	GRinf	Hill slope (GR values)	R-squared curve fit (GR values)	P-value curve fit (GR values)	IC50	Emax	AUC	EC50	Einf	Hill slope (relative cell counts)	R-squared curve fit (relative cell counts)	P-value curve fit (relative cell counts)
HCC70	QL-XII-47	2	sigmoid	sigmoid	HCC70 QL-XII-47 0 2	9	1.573	0.728	-0.818	0.401	1.07	-0.805	2.49	0.991	6.84e-36	0.901	0.0231	0.771	0.883	0.029	2.89	0.985	1.44e-31
HCC70	QL-XII-47	3	sigmoid	sigmoid	HCC70 QL-XII-47 0 3	9	1.750	0.67	-0.681	0.457	0.98	-0.726	2.37	0.993	4e-37	0.776	0.0408	0.712	0.76	0.022	2.23	0.988	1.63e-33
HCC70	QL-XII-61	1	sigmoid	sigmoid	HCC70 QL-XII-61 0 1	9	1.598	6.18	0.125	0.0875	11.5	-1.0	1.76	0.946	2.8e-22	8.07	0.399	0.937	8.07	0.0	1.9	0.932	1.35e-20
HCC70	QL-XII-61	2	sigmoid	sigmoid	HCC70 QL-XII-61 0 2	9	1.573	4.5	0.179	0.0498	4.14	0.169	5.0	0.928	3.35e-20	5.98	0.436	0.967	4.03	0.43	5.0	0.913	1.01e-18
HCC70	QL-XII-61	3	sigmoid	sigmoid	HCC70 QL-XII-61 0 3	9	1.750	6.08	0.145	0.111	12.1	-1.0	1.6	0.908	2.21e-18	7.62	0.377	0.913	7.62	0.0	1.76	0.879	2.58e-16
HCC70	Torin1	1	sigmoid	sigmoid	HCC70 Torin1 0 1	9	1.598	0.061	-0.147	0.573	0.0884	-0.134	0.64	0.954	1.68e-23	0.182	0.256	0.601	0.057	0.275	0.684	0.957	6.27e-24
HCC70	Torin1	2	sigmoid	sigmoid	HCC70 Torin1 0 2	9	1.573	0.0399	-0.322	0.653	0.107	-0.343	0.53	0.962	7.04e-25	0.123	0.183	0.557	0.0522	0.201	0.6	0.964	3.46e-25
HCC70	Torin1	3	sigmoid	sigmoid	HCC70 Torin1 0 3	9	1.750	0.0678	-0.133	0.547	0.0833	-0.0781	0.706	0.967	3.43e-25	0.133	0.232	0.596	0.0487	0.284	0.833	0.971	4.17e-26
HCC70	Torin2	1	sigmoid	sigmoid	HCC70 Torin2 0 1	9	1.598	0.014	-0.946	1.07	0.0747	-1.0	0.657	0.991	3.28e-35	0.0269	0.00323	0.362	0.0269	0.0	0.682	0.988	1.64e-33
HCC70	Torin2	2	sigmoid	sigmoid	HCC70 Torin2 0 2	9	1.573	0.0124	-0.955	1.11	0.0639	-1.0	0.669	0.99	1.92e-34	0.0242	0.00262	0.351	0.0242	0.0	0.695	0.987	7.52e-33
HCC70	Torin2	3	sigmoid	sigmoid	HCC70 Torin2 0 3	9	1.750	0.018	-0.94	1.03	0.0947	-1.0	0.661	0.992	2.34e-36	0.0285	0.00226	0.367	0.0285	0.0	0.704	0.99	4.9e-35
HCC1806	AZD8055	1	sigmoid	sigmoid	HCC1806 AZD8055 0 1	9	2.619	0.478	0.384	0.305	0.0881	0.405	0.984	0.981	4.01e-29	0.322	0.382	0.673	0.0664	0.398	1.01	0.981	4.52e-29
HCC1806	AZD8055	2	sigmoid	sigmoid	HCC1806 AZD8055 0 2	9	2.714	0.738	0.43	0.289	0.094	0.437	1.01	0.947	2.1e-22	0.387	0.402	0.678	0.0732	0.405	0.999	0.935	6.08e-21
HCC1806	AZD8055	3	sigmoid	sigmoid	HCC1806 AZD8055 0 3	9	2.697	0.249	0.382	0.325	0.0778	0.383	1.25	0.992	1.75e-36	0.177	0.369	0.652	0.061	0.37	1.26	0.992	2.49e-36
HCC1806	QL-IV-100	1	sigmoid	sigmoid	HCC1806 QL-IV-100 0 1	9	2.619	0.303	-0.286	0.47	0.414	-0.317	1.57	0.992	4.02e-36	0.274	0.0675	0.611	0.259	0.0348	1.29	0.99	8.31e-35
HCC1806	QL-IV-100	2	sigmoid	sigmoid	HCC1806 QL-IV-100 0 2	9	2.714	0.334	-0.269	0.453	0.46	-0.309	1.51	0.992	8.44e-37	0.292	0.065	0.615	0.28	0.0247	1.22	0.99	8.24e-35
HCC1806	QL-IV-100	3	sigmoid	sigmoid	HCC1806 QL-IV-100 0 3	9	2.697	0.287	-0.301	0.472	0.412	-0.344	1.45	0.995	2.12e-39	0.252	0.0588	0.608	0.24	0.0305	1.31	0.992	2.13e-36
HCC1806	QL-V-107	1	sigmoid	sigmoid	HCC1806 QL-V-107 0 1	9	2.619	0.586	-0.315	0.383	1.03	-0.442	1.12	0.993	7.41e-38	0.53	0.0606	0.662	0.53	0.0	1.07	0.989	6.64e-34
HCC1806	QL-V-107	2	sigmoid	sigmoid	HCC1806 QL-V-107 0 2	9	2.714	0.604	-0.279	0.364	1.09	-0.428	1.05	0.995	5.69e-40	0.517	0.0629	0.672	0.517	0.0	1.02	0.994	2.98e-38
HCC1806	QL-V-107	3	sigmoid	sigmoid	HCC1806 QL-V-107 0 3	9	2.697	0.519	-0.346	0.402	1.01	-0.489	1.03	0.965	1.52e-25	0.443	0.0491	0.645	0.435	0.00946	1.1	0.932	1.36e-20
HCC1806	QL-V-73	1	sigmoid	sigmoid	HCC1806 QL-V-73 0 1	9	2.619	2.14	-0.175	0.21	3.86	-0.536	1.24	0.992	6.14e-36	1.95	0.0983	0.797	1.94	0.000723	1.36	0.981	6.21e-30
HCC1806	QL-V-73	2	sigmoid	sigmoid	HCC1806 QL-V-73 0 2	9	2.714	2.24	-0.136	0.192	3.69	-0.452	1.28	0.994	5.74e-39	1.96	0.102	0.813	1.92	0.016	1.41	0.989	3.06e-34
HCC1806	QL-V-73	3	sigmoid	sigmoid	HCC1806 QL-V-73 0 3	9	2.697	1.96	-0.197	0.215	3.3	-0.482	1.29	0.994	6.63e-39	1.72	0.0855	0.793	1.68	0.0165	1.44	0.989	5.05e-34
HCC1806	QL-VI-86	1	sigmoid	sigmoid	HCC1806 QL-VI-86 0 1	9	2.619	1.41	-0.214	0.244	2.16	-0.376	1.31	0.997	1.33e-44	1.28	0.0866	0.776	1.21	0.0401	1.42	0.995	1.89e-39
HCC1806	QL-VI-86	3	sigmoid	sigmoid	HCC1806 QL-VI-86 0 3	9	2.697	1.31	-0.229	0.248	2.19	-0.42	1.2	0.994	4.5e-38	1.11	0.0766	0.771	1.02	0.0546	1.46	0.987	5.18e-33

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HMS LINCS Project

Evaluation of the sensitivity of two triple-negative breast cancer cell lines (HCC1806, HCC70) to a collection of dual mTOR and PI3K-like kinase (PIKK) inhibitors. Dataset 2 of 2: GR metrics. - Dataset (ID:20367)