Evaluation of the sensitivities of six triple-negative breast cancer (TNBC) cell lines to 23 different PI3K/AKT/mTOR inhibitors or to a MEK inhibitor (trametinib). Dataset 2 of 2: GR metrics. - Dataset (ID:20365)

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  • 1 to 25 of 432 records
Cell line Drug name Experimental replicate Timepoint Curve type (GR values) Curve type (relative cell counts) Experiment name Number of concentrations Cell doublings (DMSO control) GR50 GRmax GR_AOC GEC50 GRinf Hill slope (GR values) R-squared sigmoid fit (GR values) P-value sigmoid fit (GR values) R-squared flat fit (GR values) IC50 Emax AUC EC50 Einf Hill slope (relative cell counts) R-squared sigmoid fit (relative cell counts) P-value sigmoid fit (relative cell counts) R-squared flat fit (relative cell counts)
BT-20 AS605240 1 72
sigmoid
sigmoid
BT20 AS-605240 0 1 72
8 2.142
Inf
0.817
0.0993
3.91
0.634
0.244
0.861
0.00271
NA
Inf
0.814
0.897
3.87
0.629
0.237
0.854
0.00311
NA
BT-20 AS605240 2 72
sigmoid
sigmoid
BT20 AS-605240 0 2 72
8 1.846
4509270.0
0.729
0.203
320.0
0.31
0.101
0.845
0.00373
NA
4.4e+12
0.764
0.821
56.5
0.46
0.101
0.843
0.00388
NA
BT-20 AS605240 3 72
sigmoid
sigmoid
BT20 AS-605240 0 3 72
8 2.607
Inf
0.845
0.0823
4.13
0.662
0.292
0.729
0.0199
NA
Inf
0.81
0.897
3.97
0.589
0.284
0.712
0.0239
NA
BT-20 AZD-6482 1 72
sigmoid
sigmoid
BT20 AZD6482 0 1 72
8 2.043
1.34
0.182
0.173
3.83
-0.782
0.893
0.982
5.6e-06
NA
1.65
0.342
0.845
1.65
0.0
0.977
0.972
2.09e-05
NA
BT-20 AZD-6482 2 72
sigmoid
sigmoid
BT20 AZD6482 0 2 72
8 1.645
0.581
0.0253
0.303
3.86
-1.0
0.58
0.904
0.000884
NA
1.34
0.333
0.772
1.34
0.0
0.582
0.864
0.0025
NA
BT-20 AZD-6482 3 72
sigmoid
sigmoid
BT20 AZD6482 0 3 72
8 2.601
1.68
0.3
0.173
8.38
-1.0
0.685
0.959
6.72e-05
NA
1.5
0.326
0.805
1.5
0.0
0.733
0.925
0.000414
NA
BT-20 AZD8055 1 72
sigmoid
sigmoid
BT20 AZD8055 0 1 72
8 2.117
0.0548
0.243
0.465
0.0266
0.213
0.768
0.984
4.08e-06
NA
0.0937
0.365
0.589
0.0198
0.335
0.713
0.982
5.4e-06
NA
BT-20 AZD8055 2 72
sigmoid
sigmoid
BT20 AZD8055 0 2 72
8 1.951
0.00909
0.155
0.651
0.00651
0.115
0.785
0.936
0.000258
NA
0.0185
0.343
0.477
0.00469
0.311
0.706
0.934
0.000289
NA
BT-20 AZD8055 3 72
sigmoid
sigmoid
BT20 AZD8055 0 3 72
8 2.694
0.0351
0.345
0.472
0.0116
0.313
0.89
0.934
0.000286
NA
0.0291
0.343
0.506
0.00813
0.306
0.743
0.922
0.000471
NA
BT-20 Dactolisib 1 72
sigmoid
sigmoid
BT20 dactolisib 0 1 72
8 2.055
0.0223
-0.205
0.652
0.0609
-0.33
0.505
0.979
9.18e-06
NA
0.0305
0.15
0.475
0.0171
0.153
0.631
0.979
9.75e-06
NA
BT-20 Dactolisib 2 72
sigmoid
sigmoid
BT20 dactolisib 0 2 72
8 1.727
0.00497
-0.212
0.896
0.00652
-0.186
1.17
0.995
1.45e-07
NA
0.00801
0.2
0.382
0.00505
0.211
1.19
0.994
2.07e-07
NA
BT-20 Dactolisib 3 72
sigmoid
sigmoid
BT20 dactolisib 0 3 72
8 2.420
0.0111
0.024
0.639
0.00921
0.0987
1.17
0.982
6.27e-06
NA
0.0106
0.198
0.427
0.00645
0.241
1.32
0.99
9.14e-07
NA
BT-20 Buparlisib 1 72
sigmoid
sigmoid
BT20 buparlisib 0 1 72
8 2.131
0.598
-0.394
0.285
1.19
-0.763
1.35
0.992
4.68e-07
NA
0.663
0.0784
0.766
0.663
0.0
1.49
0.981
7.06e-06
NA
BT-20 Buparlisib 2 72
sigmoid
sigmoid
BT20 buparlisib 0 2 72
8 1.743
0.334
-0.45
0.391
0.844
-0.82
1.05
0.972
2.21e-05
NA
0.487
0.105
0.718
0.487
0.0
1.12
0.948
0.000142
NA
BT-20 Buparlisib 3 72
sigmoid
sigmoid
BT20 buparlisib 0 3 72
8 2.529
0.629
-0.303
0.26
1.06
-0.565
1.46
0.994
2.13e-07
NA
0.603
0.0696
0.764
0.603
0.0
1.52
0.984
4.36e-06
NA
BT-20 BX-912 1 72
flat
flat
BT20 BX-912 0 1 72
8 2.193
Inf
0.858
0.0928
0.0
0.858
0.01
0.25
0.422
0.903
Inf
0.851
0.901
0.0
0.851
0.01
0.243
0.433
0.897
BT-20 BX-912 2 72
flat
flat
BT20 BX-912 0 2 72
8 1.873
Inf
0.683
0.213
0.0
0.683
0.01
0.118
0.686
0.777
Inf
0.724
0.81
0.0
0.724
0.01
0.111
0.702
0.802
BT-20 BX-912 3 72
flat
flat
BT20 BX-912 0 3 72
8 2.619
Inf
0.904
0.0795
0.0
0.904
0.01
0.000173
0.999
0.918
Inf
0.879
0.9
0.0
0.879
0.01
0.00619
0.982
0.896
BT-20 Alpelisib 1 72
sigmoid
sigmoid
BT20 alpelisib 0 1 72
8 2.077
1.14
0.046
0.196
3.52
-1.0
0.977
0.966
4.1e-05
NA
1.32
0.26
0.825
1.32
0.0
1.13
0.942
0.000194
NA
BT-20 Alpelisib 2 72
sigmoid
sigmoid
BT20 alpelisib 0 2 72
8 1.692
0.253
-0.0994
0.405
2.25
-1.0
0.503
0.835
0.00451
NA
0.612
0.259
0.698
0.612
0.0
0.507
0.764
0.0131
NA
BT-20 Alpelisib 3 72
sigmoid
sigmoid
BT20 alpelisib 0 3 72
8 2.541
1.21
0.199
0.21
5.83
-1.0
0.697
0.881
0.00167
NA
1.12
0.272
0.775
1.12
0.0
0.764
0.791
0.00916
NA
BT-20 CAL-101 1 72
flat
flat
BT20 idelalisib 0 1 72
8 2.112
Inf
0.869
0.0546
0.0
0.869
0.01
0.0807
0.777
0.938
Inf
0.867
0.943
0.0
0.867
0.01
0.0778
0.784
0.936
BT-20 CAL-101 2 72
flat
flat
BT20 idelalisib 0 2 72
8 1.768
Inf
0.818
0.0943
0.0
0.818
0.01
0.226
0.463
0.898
Inf
0.845
0.918
0.0
0.845
0.01
0.222
0.471
0.912
BT-20 CAL-101 3 72
flat
flat
BT20 idelalisib 0 3 72
8 2.589
Inf
0.916
0.0535
0.0
0.916
0.01
0.0547
0.845
0.944
Inf
0.894
0.932
0.0
0.894
0.01
0.0506
0.856
0.929
BT-20 Everolimus 1 72
flat
flat
BT20 everolimus 0 1 72
8 2.002
Inf
0.546
0.403
0.0
0.546
0.01
-0.000401
1.0
0.595
Inf
0.597
0.638
0.0
0.597
0.01
-0.327
1.0
0.636
  • Page 1 of 18
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