LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_4
 Dasatinib 72
0.5549
 -0.0532 0.3996 1.34090 -0.3371 0.5842 0.9860
1.11022302463e-16
MCF10A-GM_4
 Etoposide 72
0.2814
 0.0170 0.4542 0.28897 -0.0173 1.2781 0.9882
1.11022302463e-16
MCF10A-GM_4
 Neratinib 72
0.3213
 0.0948 0.2421 0.25816 0.1783 2.0143 0.9600
4.4408920985e-16
MCF10A-GM_4
 Taxol 72
0.0035
 -0.1612 0.7179 0.00406 -0.1470 1.7773 0.9895
1.11022302463e-16
MCF10A-GM_4
 Palbociclib 72
1.2786
 0.1204 0.2510 1.13395 0.0360 0.6224 0.9308
3.10862446895e-15
MCF10A-GM_4
 Trametinib 72
0.0049
 0.1945 0.5715 0.00332 0.1878 1.2052 0.9846
1.11022302463e-16
MCF10A-GM_4
 Vorinostat 72
1.8157
 0.0972 0.2199 1.71251 0.0463 1.6610 0.9854
1.44551037806e-13
MCF10A-GM_5
 Alpelisib 72
12.6322
 0.5207 0.1108 81.30890 -1.0000 0.5900 0.9846
1.11022302463e-16
MCF10A-GM_5
 Dasatinib 72
0.6795
 -0.0849 0.3753 1.79909 -0.3886 0.5905 0.9862
1.11022302463e-16
MCF10A-GM_5
 Etoposide 72
0.2926
 0.0114 0.4454 0.29626 -0.0089 1.4036 0.9925
1.11022302463e-16
MCF10A-GM_5
 Neratinib 72
0.3964
 0.1078 0.2346 0.32649 0.1311 1.5671 0.9720
1.11022302463e-16
MCF10A-GM_5
 Taxol 72
0.0035
 -0.1747 0.7341 0.00408 -0.1521 1.6592 0.9847
1.11022302463e-16
MCF10A-GM_5
 Palbociclib 72
1.3443
 0.1381 0.2526 0.87951 0.1153 0.6180 0.9252
8.43769498715e-15
MCF10A-GM_5
 Trametinib 72
0.0055
 0.1290 0.5670 0.00383 0.1779 1.2083 0.9766
1.11022302463e-16
MCF10A-GM_5
 Vorinostat 72
2.0845
 0.0606 0.2051 2.11031 -0.0098 1.5706 0.9910
4.77395900589e-15
MCF10A-GM_6
 Alpelisib 72
13.6674
 0.5343 0.1095 92.70681 -1.0000 0.5739 0.9770
1.11022302463e-16
MCF10A-GM_6
 Dasatinib 72
0.6238
 -0.0558 0.3803 1.40075 -0.3286 0.6244 0.9838
1.11022302463e-16
MCF10A-GM_6
 Etoposide 72
0.2852
 0.0349 0.4444 0.28112 0.0099 1.3701 0.9933
1.11022302463e-16
MCF10A-GM_6
 Neratinib 72
0.3761
 0.1070 0.2321 0.31111 0.1441 1.7915 0.9747
1.11022302463e-16
MCF10A-GM_6
 Taxol 72
0.0036
 -0.1585 0.7040 0.00409 -0.1386 1.7468 0.9850
1.11022302463e-16
MCF10A-GM_6
 Palbociclib 72
1.6855
 0.1558 0.2242 1.17921 0.1046 0.6573 0.9371
9.99200722163e-16
MCF10A-GM_6
 Trametinib 72
0.0053
 0.1799 0.5666 0.00355 0.1936 1.2066 0.9871
1.11022302463e-16
MCF10A-GM_6
 Vorinostat 72
2.02
 0.0947 0.2066 1.88917 0.0560 1.7751 0.9873
5.38458166943e-14
MCF10A-GM_7
 Alpelisib 72
inf
 0.5800 0.1011 1.84960 0.5587 0.9359 0.9686
1.11022302463e-16
MCF10A-GM_7
 Dasatinib 72
0.7106
 -0.0667 0.3612 1.65872 -0.3419 0.6146 0.9852
1.11022302463e-16