LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist B in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20362)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_7
 Etoposide 72
0.3136
 0.0260 0.4219 0.30971 0.0089 1.4497 0.9861
1.11022302463e-16
MCF10A-GM_7
 Neratinib 72
0.7004
 0.1524 0.1795 0.49822 0.2115 1.6140 0.9562
1.11022302463e-15
MCF10A-GM_7
 Taxol 72
0.0042
 -0.1484 0.7164 0.00501 -0.1660 1.6732 0.9838
1.11022302463e-16
MCF10A-GM_7
 Palbociclib 72
1.4192
 0.1315 0.1975 0.46657 0.3096 0.8680 0.8643
1.44168010863e-11
MCF10A-GM_7
 Trametinib 72
0.0049
 0.1766 0.5702 0.00356 0.1886 1.4500 0.9957
1.11022302463e-16
MCF10A-GM_7
 Vorinostat 72
2.2366
 0.0823 0.2018 2.22508 0.0042 1.6213 0.9772
3.23052695705e-12
MCF10A-GM_8
 Alpelisib 72
17.8393
 0.5275 0.0998 138.06189 -1.0000 0.5369 0.9510
3.88578058619e-15
MCF10A-GM_8
 Dasatinib 72
0.7613
 -0.0880 0.3632 2.43718 -0.4869 0.5844 0.9823
1.11022302463e-16
MCF10A-GM_8
 Etoposide 72
0.3332
 0.0318 0.4204 0.33520 -0.0040 1.3426 0.9936
1.11022302463e-16
MCF10A-GM_8
 Neratinib 72
0.6706
 0.1160 0.1824 0.54699 0.1232 1.3890 0.9508
4.10782519111e-15
MCF10A-GM_8
 Taxol 72
0.0043
 -0.1715 0.7088 0.00525 -0.1769 1.5821 0.9820
1.11022302463e-16
MCF10A-GM_8
 Palbociclib 72
2.0079
 0.2005 0.1953 0.67438 0.2875 0.7841 0.9289
4.4408920985e-15
MCF10A-GM_8
 Trametinib 72
0.0053
 0.2224 0.5595 0.00373 0.2010 1.4325 0.9894
1.11022302463e-16
MCF10A-GM_8
 Vorinostat 72
2.2688
 0.0809 0.2004 2.38912 -0.0375 1.3994 0.9846
2.06834549488e-13
MCF10A-GM_9
 Alpelisib 72
40.5553
 0.6142 0.0999 7.33308 0.3417 0.6724 0.9520
1.43218770177e-14
MCF10A-GM_9
 Dasatinib 72
0.8384
 -0.0654 0.3421 1.94935 -0.3664 0.6515 0.9807
1.11022302463e-16
MCF10A-GM_9
 Etoposide 72
0.3431
 0.0499 0.4228 0.33943 0.0077 1.4363 0.9901
1.11022302463e-16
MCF10A-GM_9
 Neratinib 72
0.7213
 0.1590 0.1769 0.54736 0.1720 1.5274 0.9640
1.11022302463e-16
MCF10A-GM_9
 Taxol 72
0.0044
 -0.2005 0.6800 0.00529 -0.1770 1.6339 0.9825
1.11022302463e-15
MCF10A-GM_9
 Palbociclib 72
1.9908
 0.2644 0.1774 0.63833 0.3431 1.0190 0.9267
6.43929354283e-15
MCF10A-GM_9
 Trametinib 72
0.0052
 0.2232 0.5524 0.00366 0.2093 1.5591 0.9867
1.11022302463e-16
MCF10A-GM_9
 Vorinostat 72
2.5965
 0.1036 0.1840 2.74842 -0.0412 1.3907 0.9875
4.86277684786e-14