LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 1 of 2: Normalized growth rate inhibition values. - Dataset (ID:20358)
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Small Molecule | barcode | cell_count | frac_dead | corpse_count | cell_count_dead | row | column | agent | concentration | role | timepoint | replicate | cell_line | dead_count | fraction_dead | cell_count__time0 | dead_count__time0 | cell_count__ctrl | dead_count__ctrl | fraction_dead__ctrl | increase_fraction_dead | GRvalue |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neratinib | 180619_MC_11 | 886 | 0.1506 | 77 | 68 | 9 | 8 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_5 | 145 | 0.1406 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.11757 | 0.0753 |
Neratinib | 180619_MC_11 | 1116 | 0.1233 | 76 | 71 | 14 | 13 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_6 | 147 | 0.1164 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.09332 | 0.1311 |
Neratinib | 180619_MC_12 | 1719 | 0.0450 | 59 | 21 | 6 | 10 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_7 | 80 | 0.0445 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.02139 | 0.2433 |
Neratinib | 180619_MC_12 | 1304 | 0.1772 | 146 | 111 | 7 | 3 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_8 | 257 | 0.1646 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.14156 | 0.1703 |
Neratinib | 180619_MC_12 | 1520 | 0.1224 | 147 | 57 | 7 | 7 | Neratinib | 0.997999609 | treatment | 72 | 2 | MCF10A-GM_9 | 204 | 0.1183 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.09526 | 0.2102 |
Neratinib | 180619_MC_10 | 744 | 0.3086 | 79 | 175 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_1 | 254 | 0.2545 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.23143 | 0.0350 |
Neratinib | 180619_MC_10 | 612 | 0.4476 | 123 | 206 | 5 | 19 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_2 | 329 | 0.3496 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.32655 | -0.0083 |
Neratinib | 180619_MC_10 | 549 | 0.4209 | 102 | 172 | 9 | 9 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_3 | 274 | 0.3329 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.30985 | -0.0317 |
Neratinib | 180619_MC_11 | 858 | 0.2778 | 103 | 164 | 5 | 12 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_4 | 267 | 0.2373 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.21426 | 0.0678 |
Neratinib | 180619_MC_11 | 766 | 0.2991 | 100 | 159 | 8 | 19 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_5 | 259 | 0.2527 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.22961 | 0.0416 |
Neratinib | 180619_MC_11 | 783 | 0.2226 | 84 | 109 | 9 | 20 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_6 | 193 | 0.1977 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.17467 | 0.0466 |
Neratinib | 180619_MC_12 | 920 | 0.1792 | 107 | 77 | 4 | 22 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_7 | 184 | 0.1667 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.14359 | 0.0842 |
Neratinib | 180619_MC_12 | 900 | 0.1740 | 106 | 69 | 8 | 14 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_8 | 175 | 0.1628 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.13972 | 0.0790 |
Neratinib | 180619_MC_12 | 926 | 0.1793 | 100 | 84 | 13 | 14 | Neratinib | 3.160329364 | treatment | 72 | 2 | MCF10A-GM_9 | 184 | 0.1658 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.14269 | 0.0858 |
Taxol | 180619_MC_10 | 14915 | 0.0225 | 72 | 265 | 7 | 15 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_1 | 337 | 0.0221 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | -0.00098 | 0.9954 |
Taxol | 180619_MC_10 | 13886 | 0.0195 | 41 | 231 | 12 | 5 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_2 | 272 | 0.0192 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | -0.00386 | 0.9645 |
Taxol | 180619_MC_10 | 14425 | 0.0199 | 26 | 261 | 13 | 7 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_3 | 287 | 0.0195 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | -0.00357 | 0.9809 |
Taxol | 180619_MC_11 | 15058 | 0.0252 | 58 | 323 | 6 | 13 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_4 | 381 | 0.0247 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00160 | 0.9996 |
Taxol | 180619_MC_11 | 14710 | 0.0258 | 55 | 326 | 8 | 13 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_5 | 381 | 0.0252 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00217 | 0.9894 |
Taxol | 180619_MC_11 | 14696 | 0.0246 | 59 | 304 | 13 | 17 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_6 | 363 | 0.0241 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00103 | 0.9890 |
Taxol | 180619_MC_12 | 15484 | 0.0279 | 118 | 318 | 9 | 20 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_7 | 436 | 0.0274 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00431 | 1.0119 |
Taxol | 180619_MC_12 | 16311 | 0.0227 | 95 | 277 | 10 | 20 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_8 | 372 | 0.0223 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | -0.00078 | 1.0349 |
Taxol | 180619_MC_12 | 15528 | 0.0273 | 126 | 302 | 13 | 20 | Paclitaxel | 0.000332667 | treatment | 72 | 2 | MCF10A-GM_9 | 428 | 0.0268 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00375 | 1.0131 |
Taxol | 180619_MC_10 | 14574 | 0.0303 | 88 | 356 | 3 | 16 | Paclitaxel | 0.000998 | treatment | 72 | 2 | MCF10A-GM_1 | 444 | 0.0296 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | 0.00649 | 0.9854 |
Taxol | 180619_MC_10 | 12128 | 0.0235 | 57 | 229 | 12 | 7 | Paclitaxel | 0.000998 | treatment | 72 | 2 | MCF10A-GM_2 | 286 | 0.0230 | 635.9 | 71.1 | 15071 | 356.7 | 0.0231 | -0.00004 | 0.9071 |