Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
HME1 Alpelisib
0.031623
PI3Ka
PI3K/mTOR
 1.0105 0.00009
HME1 Alpelisib
0.1
PI3Ka
PI3K/mTOR
 0.9916 -0.00266
HME1 Alpelisib
0.31623
PI3Ka
PI3K/mTOR
 0.9314 -0.00049
HME1 Alpelisib
1.0
PI3Ka
PI3K/mTOR
 0.8736 0.00083
HME1 Alpelisib
3.1623
PI3Ka
PI3K/mTOR
 0.6972 0.00914
HME1 Alpelisib
10.0
PI3Ka
PI3K/mTOR
 0.3071 0.05531
HME1 Taselisib
0.001
PI3Ka, g, d
PI3K/mTOR
 1.0606 -0.00341
HME1 Taselisib
0.0031623
PI3Ka, g, d
PI3K/mTOR
 1.0201 -0.00139
HME1 Taselisib
0.01
PI3Ka, g, d
PI3K/mTOR
 0.9347 -0.00244
HME1 Taselisib
0.031623
PI3Ka, g, d
PI3K/mTOR
 0.7356 0.00352
HME1 Taselisib
0.1
PI3Ka, g, d
PI3K/mTOR
 0.5247 0.01134
HME1 Taselisib
0.31623
PI3Ka, g, d
PI3K/mTOR
 0.3975 0.01938
HME1 Taselisib
1.0
PI3Ka, g, d
PI3K/mTOR
 0.2212 0.05968
HME1 Taselisib
3.1623
PI3Ka, g, d
PI3K/mTOR
 0.1092 0.09815
HME1 Taselisib
10.0
PI3Ka, g, d
PI3K/mTOR
 0.0336 0.12156
HME1 TGX221
0.001
PI3Kb
PI3K/mTOR
 0.8546 0.01012
HME1 TGX221
0.0031623
PI3Kb
PI3K/mTOR
 1.0137 -0.00124
HME1 TGX221
0.01
PI3Kb
PI3K/mTOR
 1.0886 -0.00033
HME1 TGX221
0.031623
PI3Kb
PI3K/mTOR
 1.0986 -0.00190
HME1 TGX221
0.1
PI3Kb
PI3K/mTOR
 1.0904 0.00006
HME1 TGX221
0.31623
PI3Kb
PI3K/mTOR
 1.1080 -0.00286
HME1 TGX221
1.0
PI3Kb
PI3K/mTOR
 1.0759 -0.00270
HME1 TGX221
3.1623
PI3Kb
PI3K/mTOR
 1.0707 -0.00232
HME1 TGX221
10.0
PI3Kb
PI3K/mTOR
 1.0265 -0.00321
HME1 Torin2
0.0001
mTOR/ATM/ATR
PI3K/mTOR
 1.0993 -0.00113