LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 76.90 | 11.9 | Inf | Inf | 0.2209 | 0.2209 | 0.0000 | 0.3859 |
| MCF 10A-H2B-mCherry | Trametinib | 80.31 | 11.9 | Inf | Inf | 0.1537 | 0.1537 | 0.0000 | 0.4652 |
| MCF 10A-H2B-mCherry | Trametinib | 85.43 | 11.9 | Inf | Inf | 0.0455 | 0.0455 | 0.0000 | 0.6300 |
| MCF 10A-H2B-mCherry | Trametinib | 85.43 | 12.0 | Inf | Inf | 0.0802 | 0.0802 | 0.0000 | 0.6023 |
| MCF 10A-H2B-mCherry | Trametinib | 89.69 | 11.9 | Inf | Inf | -0.1007 | -0.1007 | 0.0000 | 0.7813 |
| MCF 10A-H2B-mCherry | Vorinostat | 15.08 | 11.9 | 0.692 | 0.9855 | -0.3793 | -0.3371 | 1.5502 | 0.4019 |
| MCF 10A-H2B-mCherry | Vorinostat | 16.79 | 11.9 | 0.597 | 0.8322 | -0.3837 | -0.3140 | 1.5509 | 0.4157 |
| MCF 10A-H2B-mCherry | Vorinostat | 18.49 | 11.9 | 0.5769 | 0.7432 | -0.3615 | -0.2481 | 1.6710 | 0.4087 |
| MCF 10A-H2B-mCherry | Vorinostat | 20.19 | 11.9 | 0.6033 | 0.8014 | -0.3633 | -0.2584 | 1.6052 | 0.4060 |
| MCF 10A-H2B-mCherry | Vorinostat | 21.90 | 11.9 | 0.5423 | 0.8664 | -0.2962 | -0.3081 | 1.5323 | 0.4241 |
| MCF 10A-H2B-mCherry | Vorinostat | 23.60 | 11.9 | 0.5562 | 0.8818 | -0.2455 | -0.3180 | 1.2379 | 0.4408 |
| MCF 10A-H2B-mCherry | Vorinostat | 25.30 | 11.9 | 0.5083 | 0.8386 | -0.2192 | -0.3315 | 1.1633 | 0.4556 |
| MCF 10A-H2B-mCherry | Vorinostat | 27.00 | 11.9 | 0.5682 | 0.7559 | -0.2144 | -0.2450 | 1.4849 | 0.4363 |
| MCF 10A-H2B-mCherry | Vorinostat | 28.71 | 11.9 | 0.629 | 1.0433 | -0.2095 | -0.3356 | 1.1665 | 0.4172 |
| MCF 10A-H2B-mCherry | Vorinostat | 30.41 | 11.9 | 0.7329 | 1.0073 | -0.1849 | -0.2655 | 1.4478 | 0.3993 |
| MCF 10A-H2B-mCherry | Vorinostat | 32.11 | 11.9 | 0.8119 | 1.0372 | -0.1621 | -0.2219 | 1.5568 | 0.3772 |
| MCF 10A-H2B-mCherry | Vorinostat | 33.82 | 11.9 | 0.8263 | 1.0452 | -0.1749 | -0.2229 | 1.5727 | 0.3726 |
| MCF 10A-H2B-mCherry | Vorinostat | 35.52 | 11.9 | 0.8203 | 1.1159 | -0.1907 | -0.2614 | 1.4527 | 0.3801 |
| MCF 10A-H2B-mCherry | Vorinostat | 37.23 | 11.9 | 0.9484 | 1.2769 | -0.2149 | -0.2660 | 1.5742 | 0.3599 |
| MCF 10A-H2B-mCherry | Vorinostat | 38.93 | 11.9 | 1.1 | 1.306 | -0.1733 | -0.1916 | 1.9670 | 0.3264 |
| MCF 10A-H2B-mCherry | Vorinostat | 40.63 | 11.9 | 1.1841 | 1.3562 | -0.1480 | -0.1647 | 2.5578 | 0.3101 |
| MCF 10A-H2B-mCherry | Vorinostat | 42.33 | 11.9 | 1.146 | 1.4165 | -0.1745 | -0.2133 | 1.8752 | 0.3130 |
| MCF 10A-H2B-mCherry | Vorinostat | 44.03 | 11.9 | 1.1254 | 1.4872 | -0.1917 | -0.2391 | 1.9009 | 0.3215 |
| MCF 10A-H2B-mCherry | Vorinostat | 45.74 | 11.9 | 1.2871 | 1.7456 | -0.1825 | -0.2649 | 1.8103 | 0.3021 |
| MCF 10A-H2B-mCherry | Vorinostat | 47.45 | 11.9 | 1.449 | 1.8444 | -0.1922 | -0.2247 | 2.0346 | 0.2603 |