LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Trametinib | 32.11 | 11.9 | 0.0031 | 0.0024 | 0.0500 | 0.1203 | 1.1430 | 0.6178 |
| MCF 10A-H2B-mCherry | Trametinib | 33.82 | 11.9 | 0.003 | 0.0026 | 0.0616 | 0.1292 | 1.6293 | 0.6149 |
| MCF 10A-H2B-mCherry | Trametinib | 35.52 | 11.9 | 0.0036 | 0.0031 | 0.0908 | 0.0944 | 1.1733 | 0.6178 |
| MCF 10A-H2B-mCherry | Trametinib | 37.23 | 11.9 | 0.0043 | 0.0042 | 0.0602 | 0.0536 | 1.0579 | 0.6101 |
| MCF 10A-H2B-mCherry | Trametinib | 38.93 | 11.9 | 0.0062 | 0.0061 | 0.0264 | 0.0759 | 1.1491 | 0.5681 |
| MCF 10A-H2B-mCherry | Trametinib | 40.63 | 11.9 | 0.0072 | 0.0068 | 0.0540 | 0.0361 | 1.0427 | 0.5699 |
| MCF 10A-H2B-mCherry | Trametinib | 42.33 | 11.9 | 0.0059 | 0.0053 | 0.0648 | 0.0806 | 1.0732 | 0.5725 |
| MCF 10A-H2B-mCherry | Trametinib | 44.03 | 11.9 | 0.007 | 0.0067 | 0.0180 | 0.0300 | 1.0037 | 0.5719 |
| MCF 10A-H2B-mCherry | Trametinib | 45.74 | 11.9 | 0.0074 | 0.0071 | -0.0343 | 0.0191 | 0.9687 | 0.5652 |
| MCF 10A-H2B-mCherry | Trametinib | 47.45 | 11.9 | 0.0084 | 0.0086 | -0.0949 | -0.0113 | 1.0149 | 0.5557 |
| MCF 10A-H2B-mCherry | Trametinib | 49.15 | 11.9 | 0.0098 | 0.0101 | -0.0648 | -0.0012 | 1.0180 | 0.5326 |
| MCF 10A-H2B-mCherry | Trametinib | 50.86 | 11.9 | 0.0107 | 0.012 | -0.1042 | -0.0310 | 0.9307 | 0.5301 |
| MCF 10A-H2B-mCherry | Trametinib | 52.56 | 11.9 | 0.0127 | 0.0135 | -0.1356 | -0.0271 | 0.9780 | 0.5060 |
| MCF 10A-H2B-mCherry | Trametinib | 54.25 | 11.9 | 0.0146 | 0.0184 | -0.1911 | -0.0833 | 1.2687 | 0.5001 |
| MCF 10A-H2B-mCherry | Trametinib | 55.97 | 11.9 | 0.0154 | 0.0232 | -0.2404 | -0.1358 | 1.0331 | 0.4994 |
| MCF 10A-H2B-mCherry | Trametinib | 57.67 | 11.9 | 0.0216 | 0.096 | -0.2887 | -0.4441 | 0.9366 | 0.4784 |
| MCF 10A-H2B-mCherry | Trametinib | 59.37 | 11.9 | 0.0199 | 0.0579 | -0.3026 | -0.3306 | 1.1156 | 0.4752 |
| MCF 10A-H2B-mCherry | Trametinib | 61.08 | 11.9 | 0.0225 | 0.0816 | -0.4094 | -0.4838 | 0.9123 | 0.4868 |
| MCF 10A-H2B-mCherry | Trametinib | 62.78 | 11.9 | 0.0231 | 0.0823 | -0.4067 | -0.4224 | 1.5981 | 0.4546 |
| MCF 10A-H2B-mCherry | Trametinib | 64.49 | 11.9 | 0.0231 | 0.0732 | -0.4390 | -0.3872 | 1.8528 | 0.4347 |
| MCF 10A-H2B-mCherry | Trametinib | 66.19 | 11.9 | 0.0293 | 0.0888 | -0.4739 | -0.4257 | 2.4814 | 0.4133 |
| MCF 10A-H2B-mCherry | Trametinib | 67.89 | 11.9 | 0.0343 | 0.1001 | -0.3655 | -0.4304 | 2.0867 | 0.4135 |
| MCF 10A-H2B-mCherry | Trametinib | 69.60 | 11.9 | 0.0443 | 0.1046 | -0.3407 | -0.3877 | 2.9325 | 0.3817 |
| MCF 10A-H2B-mCherry | Trametinib | 71.30 | 11.9 | 0.079 | 0.178 | -0.6252 | -0.6343 | 1.6738 | 0.3995 |
| MCF 10A-H2B-mCherry | Trametinib | 73.49 | 11.9 | Inf | Inf | -0.1619 | 0.0708 | 2.5000 | 0.4352 |