LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 15 of 15: Time-dependent dose-response metrics for biological replicate 3. - Dataset (ID:20323)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 67.89 | 11.9 | Inf | Inf | 0.9130 | 0.9130 | 0.0000 | 0.0702 |
| MCF 10A-H2B-mCherry | Vorinostat | 67.89 | 11.9 | 4.2349 | 4.3812 | -0.0390 | -0.0945 | 5.0000 | 0.1111 |
| MCF 10A-H2B-mCherry | Neratinib | 67.89 | 11.9 | 0.459 | 0.8951 | -0.6805 | -0.7165 | 3.0736 | 0.3488 |
| MCF 10A-H2B-mCherry | Trametinib | 67.89 | 11.9 | 0.0343 | 0.1001 | -0.3655 | -0.4304 | 2.0867 | 0.4135 |
| MCF 10A-H2B-mCherry | Etoposide | 67.89 | 11.9 | 0.2369 | 0.296 | -0.2685 | -0.3267 | 3.4357 | 0.5958 |
| MCF 10A-H2B-mCherry | Taxol | 67.89 | 11.9 | 0.0011 | 0.0016 | -0.4845 | -0.5264 | 3.3721 | 0.9248 |
| MCF 10A-H2B-mCherry | Trametinib | 69.60 | 11.9 | 0.0443 | 0.1046 | -0.3407 | -0.3877 | 2.9325 | 0.3817 |
| MCF 10A-H2B-mCherry | Taxol | 69.60 | 11.9 | Inf | Inf | 0.6450 | 0.3071 | 2.4999 | 0.7524 |
| MCF 10A-H2B-mCherry | Vorinostat | 69.60 | 11.9 | 4.6605 | 4.5982 | 0.1156 | 0.0327 | 5.0000 | 0.1150 |
| MCF 10A-H2B-mCherry | Alpelisib | 69.60 | 11.9 | Inf | Inf | 0.8288 | 0.8288 | 0.0000 | 0.0594 |
| MCF 10A-H2B-mCherry | Neratinib | 69.60 | 11.9 | 0.6006 | 1.0581 | -0.8627 | -0.8773 | 3.5601 | 0.3744 |
| MCF 10A-H2B-mCherry | Palbociclib | 69.60 | 11.9 | Inf | Inf | -0.4255 | -0.5524 | 1.2035 | 0.1809 |
| MCF 10A-H2B-mCherry | Etoposide | 69.60 | 11.9 | 0.2123 | 0.2955 | -0.4801 | -0.4544 | 3.3746 | 0.6655 |
| MCF 10A-H2B-mCherry | Dasatinib | 69.60 | 11.9 | Inf | Inf | -0.7093 | -0.7093 | 0.0000 | 0.3803 |
| MCF 10A-H2B-mCherry | Taxol | 71.30 | 11.9 | 0.001 | 0.0014 | 0.1323 | -0.2625 | 3.2812 | 0.7769 |
| MCF 10A-H2B-mCherry | Dasatinib | 71.30 | 11.9 | Inf | Inf | -0.7768 | -0.7768 | 0.0000 | 0.4315 |
| MCF 10A-H2B-mCherry | Etoposide | 71.30 | 11.9 | Inf | Inf | -0.6076 | -0.5220 | 0.7739 | 0.7550 |
| MCF 10A-H2B-mCherry | Vorinostat | 71.30 | 11.9 | Inf | Inf | 0.0118 | 0.0118 | 0.0000 | 0.1999 |
| MCF 10A-H2B-mCherry | Trametinib | 71.30 | 11.9 | 0.079 | 0.178 | -0.6252 | -0.6343 | 1.6738 | 0.3995 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.30 | 11.9 | Inf | Inf | 0.8057 | 0.8057 | 0.0000 | 0.0922 |
| MCF 10A-H2B-mCherry | Palbociclib | 71.30 | 11.9 | Inf | Inf | -0.2922 | -0.3418 | 1.3773 | 0.1777 |
| MCF 10A-H2B-mCherry | Neratinib | 71.30 | 11.9 | Inf | Inf | -0.7067 | -0.7067 | 0.0000 | 0.3198 |
| MCF 10A-H2B-mCherry | Dasatinib | 73.49 | 11.9 | Inf | Inf | -0.7187 | -0.7187 | 0.0000 | 0.6199 |
| MCF 10A-H2B-mCherry | Taxol | 73.49 | 11.9 | Inf | Inf | -0.8372 | -0.6518 | 0.5709 | 1.0513 |
| MCF 10A-H2B-mCherry | Vorinostat | 73.49 | 11.9 | Inf | Inf | -0.1017 | -0.1017 | 0.0000 | 0.3738 |